当前位置：
X-MOL 学术
›
Biomater. Sci.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Liquid exfoliated biocompatible WS2@BSA nanosheets with enhanced theranostic capacity.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0bm00991a Haoyang Yi 1 , Xinyue Zhou , Chaohui Zhou , Qingye Yang , Nengqin Jia
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-08-26 , DOI: 10.1039/d0bm00991a Haoyang Yi 1 , Xinyue Zhou , Chaohui Zhou , Qingye Yang , Nengqin Jia
Affiliation
|
Ultrathin transition metal dichalcogenides (TMDs) seem to have a promising future in the field of theranostic agents due to their excellent near-infrared light absorption capacity and large specific surface area. Plenty of previous studies focused on the therapeutic effects of the materials, but were less concerned with the detailed studies of biocompatibility for clinical transformation. In this work, ultrathin WS2 nanosheets coated with bovine serum protein (BSA) (WS2@BSA NSs) were selected as experimental subjects with favorable biocompatibility to explore their potential as a theranostic agent. Firstly, ultrathin WS2 nanosheets were prepared by ultrasound-assisted exfoliation using n-methyl pyrrolidone (NMP) as the liquid phase, followed by coating with bovine serum protein. The physical and chemical properties of WS2@BSA NSs were investigated. Secondly, the biocompatibility experiments that are most relevant to clinical transformation were divided into cell level experiments and in vivo experiments with zebrafish as the model organism. Finally, to explore further applications for the diagnosis and treatment of tumors, the in vitro photothermal effect and the X-ray computed tomography (CT) imaging capability of WS2@BSA NSs were investigated. The obtained results were promising in terms of biocompatibility and theranostics, which suggested the potential of WS2@BSA NSs for use as a multifunctional theranostic agent in clinics.
中文翻译：
液体剥落的生物相容性WS2 @ BSA纳米片具有增强的治疗能力。
超薄过渡金属二卤化二硫（TMDs）由于其出色的近红外光吸收能力和较大的比表面积，在治疗剂领域似乎具有广阔的前景。先前的许多研究都集中在材料的治疗效果上，但很少关注用于临床转化的生物相容性的详细研究。在这项工作中，选择涂有牛血清蛋白（BSA）（WS 2 @BSA NSs）的超薄WS 2纳米片作为具有良好生物相容性的实验对象，以探索其作为治疗治疗剂的潜力。首先，超薄WS 2个通过使用超声辅助剥离制备纳米片Ñ-甲基吡咯烷酮（NMP）作为液相，然后用牛血清蛋白包被。研究了WS 2 @BSA NSs的物理和化学性质。其次，将与临床转化最相关的生物相容性实验分为细胞水平实验和以斑马鱼为模型生物的体内实验。最后，为探索在肿瘤诊断和治疗中的进一步应用，研究了WS 2 @BSA NSs的体外光热效应和X射线计算机断层摄影（CT）成像能力。就生物相容性和治疗学而言，所获得的结果是有希望的，这表明了WS 2的潜力@BSA NSs在临床中用作多功能治疗剂。
更新日期：2020-09-16
中文翻译：
液体剥落的生物相容性WS2 @ BSA纳米片具有增强的治疗能力。
超薄过渡金属二卤化二硫（TMDs）由于其出色的近红外光吸收能力和较大的比表面积，在治疗剂领域似乎具有广阔的前景。先前的许多研究都集中在材料的治疗效果上，但很少关注用于临床转化的生物相容性的详细研究。在这项工作中，选择涂有牛血清蛋白（BSA）（WS 2 @BSA NSs）的超薄WS 2纳米片作为具有良好生物相容性的实验对象，以探索其作为治疗治疗剂的潜力。首先，超薄WS 2个通过使用超声辅助剥离制备纳米片Ñ-甲基吡咯烷酮（NMP）作为液相，然后用牛血清蛋白包被。研究了WS 2 @BSA NSs的物理和化学性质。其次，将与临床转化最相关的生物相容性实验分为细胞水平实验和以斑马鱼为模型生物的体内实验。最后，为探索在肿瘤诊断和治疗中的进一步应用，研究了WS 2 @BSA NSs的体外光热效应和X射线计算机断层摄影（CT）成像能力。就生物相容性和治疗学而言，所获得的结果是有希望的，这表明了WS 2的潜力@BSA NSs在临床中用作多功能治疗剂。
京公网安备 11010802027423号