Minimally invasive implantation of a porous scaffold of large volume into bone defect site remains a challenge. Scaffolds based on shape memory polymer (SMP) show potential to be delivered in the compact form via minimally invasive surgery. The present study chooses poly (ε-caprolactone)-diols (PCL-diols) as the SMP to cross-link carboxyl dextran via ester bonds together with particle leaching method to yield a porous SMP scaffold. The inner surfaces of porous SMP scaffold are then mineralized via in situ precipitation to yield mineralized porous SMP-hydroxyapatite (SMP-HA) scaffold. The porous SMP-HA scaffold possesses pore size of 400–500 μm, with HA particles uniformly distributed and orientationally aligned on the inner surfaces of scaffold. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) are carried out to identify the HA deposition. The phase transition temperature of the scaffold is adjusted to 38°C via changing the dosage of PCL (molecule weight: 2800) to endow the scaffold with shape deformation and fixed properties, as well as well-performed shape recovery property under body temperature. Bone marrow mesenchymal stem cells (BMSCs) adhere on the inner surfaces of SMP-HA scaffold, exhibiting larger spreading area when compared to cells adhered on SMP scaffold without HA, promoting its osteogenesis. In vivo degradation showed that the scaffold degrades completely after 6 months post-implantation. At the same time, significant tissue and capillary invasion indicated that the present porous SMP-HA scaffold hold great promise towards bone tissue engineering applications.

将大体积的多孔支架微创植入骨缺损部位仍然是一个挑战。基于形状记忆聚合物 (SMP) 的支架显示出通过微创手术以紧凑形式交付的潜力。本研究选择聚（ε-己内酯）-二醇（PCL-二醇）作为SMP，通过酯键和颗粒浸出法交联羧基葡聚糖，得到多孔SMP支架。然后通过原位矿化多孔 SMP 支架的内表面沉淀产生矿化多孔 SMP-羟基磷灰石 (SMP-HA) 支架。多孔SMP-HA支架具有400-500μm的孔径，HA颗粒均匀分布并定向排列在支架内表面。进行 X 射线衍射 (XRD) 和差示扫描量热法 (DSC) 以识别 HA 沉积。通过改变PCL（分子量：2800）的用量将支架的相变温度调节至38°C，赋予支架形状变形和固定性能，以及在体温下良好的形状恢复性能。骨髓间充质干细胞 (BMSCs) 粘附在 SMP-HA 支架的内表面，与粘附在没有 HA 的 SMP 支架上的细胞相比，表现出更大的扩散面积，促进其成骨。体内降解表明支架在植入后 6 个月后完全降解。同时，显着的组织和毛细血管侵入表明，目前的多孔 SMP-HA 支架在骨组织工程应用方面具有很大的前景。