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Targeting the gut microbiota by Asian and Western dietary constituents: a new avenue for diabetes.
Toxicology Research ( IF 2.1 ) Pub Date : 2020-08-25 , DOI: 10.1093/toxres/tfaa065
Abdul Rahman Conteh 1 , Ruixue Huang 1
Affiliation  

Increasing numerous diabetes annually is a great concern in public health globally. Gut microbiota recently has been suggested to be an emerging organ acting as a critical regulator in diabetes. Notably, gut microbiota is closely affected through an individual’s nutrient intake and dietary pattern. Moreover, the metabolites of diets through gut microbiota are closely associated with the development of diabetes. Increasing evidence has established the association of different dietary pattern with alterations of the gut microbiota profile, in particular, the Asian diet and Western diet are typically as essential components linked to the interactions between gut microbiota and induction of obesity which is a significant risk factor for diabetes. In addition, some bacteria-related therapeutic methods including probiotics, dietary short-chain fatty acids immunotherapy, and gut microbiome transfer would be applied in the clinical prevention and control diabetes. Taken together, based on current published observations, the gut microbiota may serve as regulator or targets by the Asian diet and Western diet, contributing to the prevention or induction of diabetes eventually. In general, in the upcoming future, one of the emerging strategies for the prevention and control of diabetes may modulate gut microbiota through precise dietary strategies.

中文翻译:

亚洲和西方饮食成分靶向肠道微生物群:糖尿病的新途径。

每年增加的糖尿病人数是全球公共卫生的一个重大问题。肠道微生物群最近被认为是一种新兴器官,可作为糖尿病的关键调节剂。值得注意的是,肠道微生物群受到个体营养摄入和饮食模式的密切影响。此外,饮食通过肠道微生物群的代谢产物与糖尿病的发展密切相关。越来越多的证据表明,不同饮食模式与肠道微生物群的改变之间存在关联,特别是亚洲饮食和西方饮食通常是与肠道微生物群和诱发肥胖之间相互作用的重要组成部分,肥胖是导致肥胖的重要危险因素。糖尿病。此外,一些与细菌相关的治疗方法包括益生菌、膳食短链脂肪酸免疫治疗和肠道微生物组转移将应用于临床预防和控制糖尿病。总之,根据目前发表的观察,肠道微生物群可能成为亚洲饮食和西方饮食的调节剂或目标,最终有助于预防或诱发糖尿病。总的来说,在即将到来的未来,预防和控制糖尿病的新兴策略之一可能会通过精确的饮食策略来调节肠道微生物群。
更新日期:2020-09-03
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