Antimicrobial peptides (AMPs) have been regarded as a potential weapon to fight against drug-resistant bacteria, which is threating the globe. Thus, more and more AMPs had been designed or identified. There is a need to integrate them into a platform for researchers to facilitate investigation and analyze existing AMPs. The AMP database has become an important tool for the discovery and transformation of AMPs as agents. A database linking antimicrobial peptides (LAMPs), launched in 2013, serves as a comprehensive tool to supply exhaustive information of AMP on a single platform. LAMP2, an updated version of LAMP, holds 23 253 unique AMP sequences and expands to link 16 public AMP databases. In the current version, there are more than 50% (12 236) sequences only linking a single database and more than 45% of AMPs linking two or more database links. Additionally, updated categories based on primary structure, collection, composition, source and function have been integrated into LAMP2. Peptides in LAMP2 have been integrated in 8 major functional classes and 38 functional activities. More than 89% (20 909) of the peptides are experimentally validated peptides. A total of 1924 references were extracted and regarded as the evidence for supporting AMP activity and cytotoxicity. The updated version will be helpful to the scientific community.

中文翻译：

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LAMP2：连接抗菌肽的数据库的重大更新。

抗菌肽（AMPs）被认为是对抗威胁全球的耐药菌的潜在武器。因此，已经设计或确定了越来越多的AMP。有必要将它们集成到研究人员的平台中，以方便调查和分析现有AMP。AMP数据库已经成为发现和转换AMP作为代理的重要工具。连接抗菌肽（LAMP）的数据库于2013年启动，可作为一个综合工具，在一个平台上提供AMP的详尽信息。LAMP2是LAMP的更新版本，拥有23 253个唯一AMP序列，并扩展为链接16个公共AMP数据库。在当前版本中，有超过50％（12 236）的序列仅链接单个数据库，而超过45％的AMP链接两个或多个数据库链接。此外，基于主要结构，集合，成分，来源和功能的更新类别已集成到LAMP2中。LAMP2中的肽已整合到8个主要功能类别和38个功能活动中。超过89％（20 909）的肽是经过实验验证的肽。总共提取了1924份参考文献，并视为支持AMP活性和细胞毒性的证据。更新的版本将对科学界有所帮助。总共提取了1924份参考文献，并视为支持AMP活性和细胞毒性的证据。更新的版本将对科学界有所帮助。总共提取了1924份参考文献，并视为支持AMP活性和细胞毒性的证据。更新的版本将对科学界有所帮助。