Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing.,Nature Human Behaviour

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Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing.
Nature Human Behaviour ( IF 21.4 ) Pub Date : 2020-08-26 , DOI: 10.1038/s41562-020-00944-2
William E Allen _{1,

2,

3} , Han Altae-Tran _{1,

3,

4} , James Briggs _{1,

3,

5} , Xin Jin _{1,

2,

3} , Glen McGee _{1,

6} , Andy Shi _{1,

6} , Rumya Raghavan _{1,

3,

7} , Mireille Kamariza _{1,

2,

3} , Nicole Nova _{1,

8} , Albert Pereta ₁ , Chris Danford ₁ , Amine Kamel ₁ , Patrik Gothe ₁ , Evrhet Milam ₁ , Jean Aurambault ₁ , Thorben Primke ₁ , Weijie Li ₁ , Josh Inkenbrandt ₁ , Tuan Huynh ₁ , Evan Chen ₁ , Christina Lee ₁ , Michael Croatto ₁ , Helen Bentley ₁ , Wendy Lu ₁ , Robert Murray ₁ , Mark Travassos _{1,

9} , Brent A Coull ₆ , John Openshaw _{1,

10} , Casey S Greene _{1,

11} , Ophir Shalem _{1,

12} , Gary King _{1,

13} , Ryan Probasco ₁ , David R Cheng ₁ , Ben Silbermann ₁ , Feng Zhang _{1,

3,

4,

14,

15,

16} , Xihong Lin _{1,

3,

6,

17}

Affiliation

The How We Feel Project, San Leandro, CA, USA.
Society of Fellows, Harvard University, Cambridge, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Schmidt Science Fellows, Oxford, UK.
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Health Sciences and Technology Program, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA, USA.
Department of Biology, Stanford University, Stanford, CA, USA.
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Albert J. Weatherhead III University Professor, Institute for Quantitative Social Sciences, Harvard University, Cambridge, MA, USA.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Department of Statistics, Harvard University, Cambridge, MA, USA.

Despite the widespread implementation of public health measures, coronavirus disease 2019 (COVID-19) continues to spread in the United States. To facilitate an agile response to the pandemic, we developed How We Feel, a web and mobile application that collects longitudinal self-reported survey responses on health, behaviour and demographics. Here, we report results from over 500,000 users in the United States from 2 April 2020 to 12 May 2020. We show that self-reported surveys can be used to build predictive models to identify likely COVID-19-positive individuals. We find evidence among our users for asymptomatic or presymptomatic presentation; show a variety of exposure, occupational and demographic risk factors for COVID-19 beyond symptoms; reveal factors for which users have been SARS-CoV-2 PCR tested; and highlight the temporal dynamics of symptoms and self-isolation behaviour. These results highlight the utility of collecting a diverse set of symptomatic, demographic, exposure and behavioural self-reported data to fight the COVID-19 pandemic.

中文翻译：

COVID-19 症状、行为和测试的人口规模纵向映射。

尽管广泛实施了公共卫生措施，2019 年冠状病毒病 (COVID-19) 仍在美国继续传播。为了促进对这一流行病的敏捷反应，我们开发了 How We Feel，这是一个网络和移动应用程序，用于收集有关健康、行为和人口统计的纵向自我报告调查答复。在此，我们报告了 2020 年 4 月 2 日至 2020 年 5 月 12 日期间美国超过 500,000 名用户的结果。我们表明，自我报告的调查可用于构建预测模型，以识别可能的 COVID-19 阳性个体。我们在用户中发现无症状或症状前表现的证据；显示除症状外的各种接触、职业和人口统计风险因素的 COVID-19；揭示用户接受 SARS-CoV-2 PCR 测试的因素；并强调症状和自我隔离行为的时间动态。这些结果凸显了收集各种症状、人口统计、暴露和行为自我报告数据来对抗 COVID-19 大流行的效用。

更新日期：2020-08-26

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