Alzheimer Disease & Associated Disorders ( IF 1.8 ) Pub Date : 2020-07-01 , DOI: 10.1097/wad.0000000000000403 Daan K L Sleutjes 1 , Iris J Harmsen 1 , Floor S van Bergen 1 , Joukje M Oosterman 2 , Paul L J Dautzenberg 1 , Roy P C Kessels 2, 3, 4
This study examined the utility of the recently published MMSE-2:SV in detecting cognitive impairment. We used receiver operating characteristics to test the discriminative power of the MMSE-2:SV for distinguishing between older adults without mild cognitive impairment (MCI) or dementia (n=67) and patients with MCI (n=76) or dementia (n=79). The results show that the MMSE-2:SV had excellent discriminative ability in distinguishing older controls from patients with dementia, with cut-off scores of 26 and 27 (max=30) yielding appropriate sensitivity (0.810 and 0.924, respectively) and specificity (0.940 and 0.806). Discriminative power was close to good in distinguishing between older controls and patients with MCI. Here, however, no optimal cut-off point could be determined. Even though this study shows good sensitivity and adequate specificity for the MMSE-2:SV in discriminating individuals without MCI or dementia from those with dementia, its validity is limited for identifying patients with MCI.
中文翻译:
迷你精神状态检查 2 在诊断荷兰门诊患者轻度认知障碍和痴呆症中的有效性。
本研究检验了最近发表的 MMSE-2:SV 在检测认知障碍方面的效用。我们使用接收器操作特征来测试 MMSE-2:SV 区分没有轻度认知障碍 (MCI) 或痴呆 (n=67) 的老年人和患有 MCI (n=76) 或痴呆 (n= 79)。结果表明,MMSE-2:SV 在区分老年对照和痴呆患者方面具有出色的区分能力,截止分数为 26 和 27(最大值 = 30),产生适当的敏感性(分别为 0.810 和 0.924)和特异性( 0.940 和 0.806)。区分老年对照和 MCI 患者的辨别力接近良好。然而,这里无法确定最佳截止点。