ABSTRACT

Firstly, the polyvinyl alcohol/polyacrylic acid double network hydrogels were prepared by physical and chemical double cross-linking, then polyethylene glycol, chitosan, and hydroxypropyl methyl cellulose were added to construct the multiple network hydrogels. The intermolecular chains were entangled with each other and the intermolecular force was gathered at the cross-linking point, which greatly improved the mechanical strength of the hydrogel. Intensity can be regulated by adjusting variables. The method used in this paper is simple and the hydrogel has better mechanical properties. Also, the raw material is nontoxic, harmless, and has a prospect application in the field of tissue engineering.

摘要

首先，通过物理和化学双交联制备聚乙烯醇/聚丙烯酸双网络水凝胶，然后加入聚乙二醇，壳聚糖和羟丙基甲基纤维素以构建多网络水凝胶。分子间链相互缠结，在交联点聚集分子间力，大大提高了水凝胶的机械强度。强度可以通过调节变量来调节。本文所用方法简单，水凝胶具有较好的机械性能。而且，该原料是无毒的，无害的，并且在组织工程领域中具有潜在的应用前景。