Abstract

In the present research ibuprofen (IBP) uptake, considered as a pharmaceutical and personal care product (PPCP), using synthesized copper-based metal-organic framework (MOF), HKUST-1, modified by dimethyl ethylenediamine (HKUST-1-mmen) was investigated. The structure of nano-composite and functional groups was characterized using SEM, EDX, FTIR, XRD, and BET analysis. Also, to optimize the experiments of IBP adsorption over HKUST-1-mmen, response surface methodology (RSM) was applied with three variables including pH, adsorbent dosage and contact time using central composite design (CCD). The optimum conditions for pH, adsorbent dosage and contact time were 3, 0.1 g and 83 min, respectively with IBP adsorption efficiency of 86.53%. The equilibrium data were compatible with Langmuir isotherm (q_m = 1000 mg g⁻¹) than other isotherm models, indicating the monolayer adsorption of IBP. According to the characteristics of IBP, HKUST-1, and the results of FTIR analysis, the adsorption of IBP on HKUST-1-mmen was through three possible mechanisms including H-bonding formation, interaction between unsaturated copper sites of HKUST-1 and -COOH from IBP and π–π stacking interactions. The kinetic studies also revealed that the Lagergren model was predominant and IBP was not chemisorbed on nano-composite surface. It was concluded from the thermodynamic parameters that the IBP adsorption was spontaneous, endothermic, and physical.

摘要

在目前的研究中，布洛芬 (IBP) 被认为是一种药物和个人护理产品 (PPCP)，使用合成的铜基金属有机骨架 (MOF) HKUST-1，经二甲基乙二胺 (HKUST-1-mmen) 改性被调查。使用SEM、EDX、FTIR、XRD和BET分析表征纳米复合材料和官能团的结构。此外，为了优化 IBP 在 HKUST-1-mmen 上的吸附实验，响应面法 (RSM) 使用三个变量，包括 pH、吸附剂剂量和使用中心复合设计 (CCD) 的接触时间。pH、吸附剂用量和接触时间的最佳条件分别为3、0.1 g和83 min，IBP吸附效率为86.53%。平衡数据与朗缪尔等温线 ( q _m= 1000 mg g ^-1 ) 比其他等温线模型，表明 IBP 的单层吸附。根据IBP、HKUST-1的特性和FTIR分析结果，IBP在HKUST-1-mmen上的吸附可能通过氢键形成、HKUST-1不饱和铜位点之间的相互作用和-来自 IBP 和 π-π 堆积相互作用的 COOH。动力学研究还表明，Lagergren 模型占主导地位，并且 IBP 没有化学吸附在纳米复合材料表面。从热力学参数得出结论，IBP 吸附是自发的、吸热的和物理的。