Background

The resistance exercise has drawn considerable attention to the level of insulin-like growth factor 1 in the serum. However, the relationship between resistance exercise and the level of insulin-like growth factor 1 in the serum is conflicting. This meta-analysis was performed to evaluate this relationship.

Methods

A systematic literature search up to May 2020 was performed and 22 studies were detected with 680 subjects. They reported relationships between resistance exercise and the level of insulin-like growth factor 1 in the serum. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated comparing the resistance exercise and the level of insulin-like growth factor 1 in the serum using the continuous method with a random or fixed-effect model.

Results

Significantly higher insulin-like growth factor 1 was observed in subjects performing resistance training for less than 16 weeks (OR, 4.03; 95% CI, 2.49–5.57, p<.001); subjects performing resistance training for more than 16 weeks (OR, 11.55; 95% CI, 6.58–16.52, p<.001); subjects older than 60 years (OR, 11.88; 95% CI, 9.84–13.93, p<.001); females (OR, 3.87; 95% CI, 2.26–5.49, p<.001) and males (OR, 16.82; 95% CI, 7.29–26.35, p<.001). However, significantly lower insulin-like growth factor 1 was observed in subjects younger than 60 years (OR, −4.80; 95% CI, −7.74 to −1.86, p=.001).

Conclusions

However, the resistance exercise significantly increases insulin-like growth factor 1 in subjects older than 60 years, both males and females, and subjects performing resistance exercise for all any period. Surprisingly, resistance exercise significantly decreases insulin-like growth factor 1 in subjects younger than 60 years. This relationship forces us to recommend the resistance exercise to improve insulin-like growth factor 1 in serum.

中文翻译：

---

阻力训练对血清中血清胰岛素样生长因子 1 的影响：一项荟萃分析。

背景

抗阻运动引起了人们对血清中胰岛素样生长因子 1 水平的极大关注。然而，抗阻运动与血清中胰岛素样生长因子 1 水平之间的关系是相互矛盾的。进行这项荟萃分析以评估这种关系。

方法

进行了截至 2020 年 5 月的系统文献检索，共检测到 22 项研究，涉及 680 名受试者。他们报告了抗阻运动与血清中胰岛素样生长因子 1 水平之间的关系。使用具有随机或固定效应模型的连续方法比较阻力运动和血清中胰岛素样生长因子 1 的水平，计算出具有 95% 置信区间 (CI) 的优势比 (OR)。

结果

在进行阻力训练少于 16 周的受试者中观察到显着更高的胰岛素样生长因子 1（OR，4.03；95% CI，2.49–5.57，p <.001）；受试者进行阻力训练超过 16 周（OR，11.55；95% CI，6.58–16.52，p <.001）；60 岁以上的受试者（OR，11.88；95% CI，9.84–13.93，p <.001）；女性 (OR, 3.87; 95% CI, 2.26–5.49, p <.001) 和男性 (OR, 16.82; 95% CI, 7.29–26.35, p <.001)。然而，在 60 岁以下的受试者中观察到胰岛素样生长因子 1 显着降低（OR，-4.80；95% CI，-7.74 至 -1.86，p =.001）。

结论

然而，抵抗运动显着增加了 60 岁以上的受试者（男性和女性）以及在任何时期进行抵抗运动的受试者的胰岛素样生长因子 1。令人惊讶的是，抗阻运动显着降低了 60 岁以下受试者的胰岛素样生长因子 1。这种关系迫使我们推荐抗阻运动以改善血清中的胰岛素样生长因子 1。