ABSTRACT

Objectives

The aim of this study was to evaluate the safety and efficacy of the use of FG-SVFs in face rejuvenation for esthetic improvement.

Methods

33 female patients affected by face’s soft-tissue defects with loss of volume, study group (SG), were treated with FG-SVFs, comparing results with a control group (CG) (n = 30) treated with fat graft not enhanced (FG). Clinical evaluation, a photographic assessment, magnetic resonance imaging (MRI), and ultrasound (US) were performed. Post-operative follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually.

Results

SG patients showed 61% maintenance of the contour restoring and of volume after 3 years compared with the CG treated with FG, who showed 31% maintenance. 60.7% (n = 20) of SG patients, presented an increase of 6.6 mm in the soft tissue volume after 36 months, which was reported in only 33,3% (n = 10) of the CG. Volumetric persistence in the SG was higher than that in the CG (p <. 0001 vs. CG). MRI and US moreover confirmed the absence of important side effects, as fat necrosis, and cytosteatonecrotic areas.

Conclusions

The use of FG-SVFs was safe and effective in this series of a case treated.

中文翻译：

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基质血管部分细胞的再生应用增强了脂肪移植物的维持：面部年轻化的临床评估。

摘要

目标

这项研究的目的是评估FG-SVF在面部修复中改善美学的安全性和有效性。

方法

研究组（SG）对33例因面部软组织缺损而体积减少的女性患者进行了FG-SVFs治疗，并将结果与​​未进行脂肪移植（FG）的对照组（CG）（n = 30）进行了比较）。进行了临床评估，照相评估，磁共振成像（MRI）和超声（US）。术后随访分别在第1、3、7、12、24、48周进行，然后每年进行一次。

结果

与FG治疗的CG患者相比，SG患者3年后的轮廓恢复和体积维持了61％的维持率，而FG治疗的CG患者显示了31％的维持率。60.7％（n = 20）的SG患者在36个月后软组织体积增加了6.6 mm，据报道只有CG的33,3％（n = 10）。SG中的体积持久性高于CG（p <.0001 vs. CG）。此外，MRI和US证实不存在重要的副作用，如脂肪坏死和细胞甾体坏死区域。

结论

在此系列病例中，使用FG-SVF是安全有效的。