Ceftazidime-avibactam is a potent antibiotic combination against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae. Here, we describe a unique ceftazidime-avibactam-resistant and carbapenem-susceptible K. pneumoniae strain harboring a novel bla_KPC-14 variant. This strain was isolated from a New York City patient in 2003, which predates the introduction of avibactam. Despite resistance to ceftazidime-avibactam, the strain was susceptible to imipenem-relebactam and meropenem-vaborbactam. Comprehensive genomic sequencing revealed that bla_KPC-14 is harbored on an ST6 IncN plasmid associated with the early spread of bla_KPC.

中文翻译：

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在纽约市分离出的头孢他啶-阿维巴坦耐药性和碳青霉烯类肺炎克雷伯菌携带 bla KPC-14 菌株。

头孢他啶-阿维巴坦是一种有效的抗生素组合，可对抗产肺炎克雷伯菌碳青霉烯酶 (KPC) 的肠杆菌科细菌。在这里，我们描述了一种独特的头孢他啶-阿维巴坦耐药和碳青霉烯敏感的肺炎克雷伯菌菌株，它含有一种新型的bla _KPC-14变体。该菌株于 2003 年从纽约市的一名患者中分离出来，这早于 avibactam 的引入。尽管对头孢他啶-阿维巴坦耐药，但该菌株对亚胺培南-瑞巴坦和美罗培南-vaborbactam 敏感。综合基因组测序显示bla _KPC-14包含在与bla _KPC的早期传播相关的 ST6 IncN 质粒上。