Simultaneous multi-slice spin- and gradient-echo dynamic susceptibility-contrast perfusion-weighted MRI of gliomas.,NMR in Biomedicine

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Simultaneous multi-slice spin- and gradient-echo dynamic susceptibility-contrast perfusion-weighted MRI of gliomas.
NMR in Biomedicine ( IF 2.7 ) Pub Date : 2020-08-25 , DOI: 10.1002/nbm.4399
Misung Han ₁ , Baolian Yang ₂ , Brice Fernandez ₃ , Marisa Lafontaine ₁ , Paula Alcaide-Leon ₁ , Angela Jakary ₁ , Brian L Burns ₄ , Melanie A Morrison ₁ , Javier E Villanueva-Meyer ₁ , Susan M Chang ₅ , Suchandrima Banerjee ₄ , Janine M Lupo _{1,

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Affiliation

Although combined spin‐ and gradient‐echo (SAGE) dynamic susceptibility‐contrast (DSC) MRI can provide perfusion quantification that is sensitive to both macrovessels and microvessels while correcting for T₁‐shortening effects, spatial coverage is often limited in order to maintain a high temporal resolution for DSC quantification. In this work, we combined a SAGE echo‐planar imaging (EPI) sequence with simultaneous multi‐slice (SMS) excitation and blipped controlled aliasing in parallel imaging (blipped CAIPI) at 3 T to achieve both high temporal resolution and whole brain coverage. Two protocols using this sequence with multi‐band (MB) acceleration factors of 2 and 3 were evaluated in 20 patients with treated gliomas to determine the optimal scan parameters for clinical use. ΔR₂*(t) and ΔR₂(t) curves were derived to calculate dynamic signal‐to‐noise ratio (dSNR), ΔR₂*‐ and ΔR₂‐based relative cerebral blood volume (rCBV), and mean vessel diameter (mVD) for each voxel. The resulting SAGE DSC images acquired using MB acceleration of 3 versus 2 appeared visually similar in terms of image distortion and contrast. The difference in the mean dSNR from normal‐appearing white matter (NAWM) and that in the mean dSNR between NAWM and normal‐appearing gray matter were not statistically significant between the two protocols. ΔR₂*‐ and ΔR₂‐rCBV maps and mVD maps provided unique contrast and spatial heterogeneity within tumors.

中文翻译：

神经胶质瘤的同时多层自旋和梯度回波动态磁化率对比灌注加权 MRI。

尽管联合自旋和梯度回波 (SAGE) 动态磁敏感对比 (DSC) MRI 可以提供对大血管和微血管均敏感的灌注量化，同时校正T ₁缩短效应，但空间覆盖通常受到限制，以保持DSC 定量的高时间分辨率。在这项工作中，我们将 SAGE 回波平面成像 (EPI) 序列与同步多切片 (SMS) 激发和并行成像中的 blipped 控制混叠 (blipped CAIPI) 相结合，以 3 T 实现高时间分辨率和全脑覆盖。在 20 名接受治疗的神经胶质瘤患者中评估了使用该序列的两种方案，多频带 (MB) 加速因子为 2 和 3，以确定临床使用的最佳扫描参数。Δ ř推导出₂ *( t ) 和 Δ R ₂ ( t ) 曲线以计算动态信噪比 (dSNR)、Δ R ₂ *- 和 Δ R _{2 -}基于相对脑血容量 (rCBV) 和平均血管每个体素的直径 (mVD)。使用 3 与 2 的 MB 加速获得的 SAGE DSC 图像在图像失真和对比度方面在视觉上相似。两种方案之间与正常出现的白质 (NAWM) 的平均 dSNR 和 NAWM 与正常出现的灰质之间的平均 dSNR 的差异无统计学意义。Δ R ₂ *- 和 Δ R ₂‐rCBV 图和 mVD 图提供了肿瘤内独特的对比度和空间异质性。

更新日期：2020-08-25

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