Diabetes is the largest global epidemic of the 21st century, and the cost of diabetes and its complications comprise about 12% of global health expenditure. Diabetic neuropathy is the most common complication of diabetes, affecting up to 50% of patients over the course of their disease. Among them, 30%–50% develop neuropathic pain, which has typical symptoms that originate from the toes and progress to foot ulcers and seriously influence quality of life. The pathogenesis of diabetic neuropathic pain (DNP) is complicated and incompletely understood and there is no effective treatment except supportive treatment. Long noncoding RNAs (lncRNAs), a class of noncoding RNAs exceeding 200 nucleotides in length, have been shown to play key roles in fundamental cellular processes, and are considered to be potential targets for treatment. Recent research indicates that lncRNA is involved in the pathogenesis of DNP. Certain overexpressed lncRNAs can enhance the purinergic receptor‐mediated neuropathic pain in peripheral ganglia and inflammatory cytokines are released due to receptors activated by adenosine triphosphate. In recent years, our laboratory also has been exploring the relationship and pathogenesis between lncRNAs and DNP. In this review, we focus on the recent progress in functional lncRNAs associated with DNP and investigate their roles related to respective receptors.

中文翻译：

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参与MAPK途径机制的长非编码RNA介导糖尿病性神经性疼痛。

糖尿病是21世纪全球最大的流行病，糖尿病及其并发症的费用约占全球卫生支出的12％。糖尿病性神经病是糖尿病最常见的并发症，在其病程中影响多达50％的患者。其中，有30％–50％的人会出现神经性疼痛，其典型症状来自脚趾并发展为足部溃疡，并严重影响生活质量。糖尿病性神经性疼痛（DNP）的发病机制复杂且尚未完全了解，除支持治疗外，没有有效的治疗方法。长的非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码RNA，已显示在基本细胞过程中起关键作用，并被认为是潜在的治疗靶标。最近的研究表明lncRNA参与DNP的发病机制。某些过表达的lncRNA可以增强嘌呤能受体介导的周围神经节的神经性疼痛，并且由于三磷酸腺苷激活的受体而释放出炎性细胞因子。近年来，我们的实验室也一直在探索lncRNA与DNP之间的关系和发病机理。在这篇综述中，我们着眼于与DNP相关的功能性lncRNA的最新进展，并研究它们与各个受体相关的作用。我们的实验室也一直在探索lncRNA与DNP之间的关系和发病机理。在这篇综述中，我们着眼于与DNP相关的功能性lncRNA的最新进展，并研究它们与各个受体相关的作用。我们的实验室也一直在探索lncRNA与DNP之间的关系和发病机理。在这篇综述中，我们着眼于与DNP相关的功能性lncRNA的最新进展，并研究它们与各个受体相关的作用。