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Cholesterol-conjugated bovine serum albumin nanoparticles as a tamoxifen tumor-targeted delivery system.
Cell Biology International ( IF 3.3 ) Pub Date : 2020-08-25 , DOI: 10.1002/cbin.11455 Mahmoud Gharbavi 1, 2, 3 , Behrooz Johari 4, 5 , Seyed Sadegh Eslami 6 , Navid Mousazadeh 5 , Ali Sharafi 3
Cell Biology International ( IF 3.3 ) Pub Date : 2020-08-25 , DOI: 10.1002/cbin.11455 Mahmoud Gharbavi 1, 2, 3 , Behrooz Johari 4, 5 , Seyed Sadegh Eslami 6 , Navid Mousazadeh 5 , Ali Sharafi 3
Affiliation
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In the present study, we introduced cholesterol (CLO)‐conjugated bovine serum albumin nanoparticles (BSA NPs) as a new system for indirect targeting drug delivery. Tamoxifen, as an anticancer drug, was loaded on BSA NPs (BSA‐TAX NPs); CLO was then conjugated to the BSA‐TAX NPs surface for the targeted delivery of NPs system, by 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide/N‐hydroxy succinimide carbodiimide chemistry (CLO‐BSA‐TAX NPs). The physicochemical properties, toxicity, in vitro, and in vivo biocompatibility of the BSA NPs system were characterized on cancer cell lines (4T1). The results revealed that the BSA NPs system has a regular spherical shape and negative zeta‐potential values. The drug release of BSA NPs system has shown controlled and pH‐dependent drug release behavior. BSA NPs system was biocompatible but it was potentially toxic on the cancer cell line. The CLO‐BSA‐TAX NPs exhibited higher toxicity against cancer cell lines than other NPs formulation (BSA NPs and BSA‐TAX NPs). It can be concluded that the CLO, as an indirect targeting agent, enhances the toxicity and specificity of NPs system on cancer cell lines. It could potentially be suitable approaches to targeting the tumors in clinical cancer therapy.
中文翻译：
胆固醇偶联的牛血清白蛋白纳米颗粒作为他莫昔芬肿瘤靶向的递送系统。
在本研究中，我们引入了胆固醇（CLO）偶联的牛血清白蛋白纳米颗粒（BSA NPs）作为间接靶向药物递送的新系统。他莫昔芬是一种抗癌药，已装载在BSA NP（BSA-TAX NP）上；然后通过1-乙基-3-（3-二甲基氨基丙基）碳二亚胺/ N-羟基琥珀酰亚胺碳二亚胺化学（CLO-BSA-TAX NP）将CLO偶联到BSA-TAX NPs表面上，以实现NPs系统的靶向递送。BSA NPs系统的理化特性，毒性，体外和体内生物相容性在癌细胞系（4T1）上进行了表征。结果表明，BSA NPs系统具有规则的球形形状和负电势。BSA NPs系统的药物释放表现出受控且依赖pH值的药物释放行为。BSA NPs系统具有生物相容性，但对癌细胞系具有潜在毒性。与其他NP制剂（BSA NP和BSA-TAX NP）相比，CLO-BSA-TAX NP对癌细胞系的毒性更高。可以得出结论，作为间接靶向剂的CLO增强了NPs系统对癌细胞系的毒性和特异性。它可能是在临床癌症治疗中靶向肿瘤的合适方法。
更新日期：2020-08-25
中文翻译：
胆固醇偶联的牛血清白蛋白纳米颗粒作为他莫昔芬肿瘤靶向的递送系统。
在本研究中，我们引入了胆固醇（CLO）偶联的牛血清白蛋白纳米颗粒（BSA NPs）作为间接靶向药物递送的新系统。他莫昔芬是一种抗癌药，已装载在BSA NP（BSA-TAX NP）上；然后通过1-乙基-3-（3-二甲基氨基丙基）碳二亚胺/ N-羟基琥珀酰亚胺碳二亚胺化学（CLO-BSA-TAX NP）将CLO偶联到BSA-TAX NPs表面上，以实现NPs系统的靶向递送。BSA NPs系统的理化特性，毒性，体外和体内生物相容性在癌细胞系（4T1）上进行了表征。结果表明，BSA NPs系统具有规则的球形形状和负电势。BSA NPs系统的药物释放表现出受控且依赖pH值的药物释放行为。BSA NPs系统具有生物相容性，但对癌细胞系具有潜在毒性。与其他NP制剂（BSA NP和BSA-TAX NP）相比，CLO-BSA-TAX NP对癌细胞系的毒性更高。可以得出结论，作为间接靶向剂的CLO增强了NPs系统对癌细胞系的毒性和特异性。它可能是在临床癌症治疗中靶向肿瘤的合适方法。
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