Non-alcoholic fatty liver(NAFLD) is prevalent in Asians despite the low obesity rate. We hypothesized that the haplotype of genetic variants in the 22q13 loci has a strong association with non-alcoholic fatty liver disease (NAFLD) that can be identified by genome-wide association study and that lifestyles may interact with the haplotype. We tested the hypothesis in middle-aged and elderly adults in a large city hospital-based cohort from the KoGES study. Men and women diagnosed with fatty liver, but who respectively consumed over 40 and 30 g ethanol per day were excluded. The haplotype of the selected SNPs from the 22q13 loci that influences NAFLD risk was generated. Among the 27374 participants, 1486 (5.4%) were diagnosed with NAFLD. LARGE_rs240072, RBFOX2_rs11089778, TRIOBP_rs12628603, PNPLA3_rs738409, and PARVB_rs2073080 in the 22q13 loci were included in the haplotype. Participants with the minor haplotype had 1.8, 2.3, and 1.8 times higher in the risk for NAFLD and serum AST and ALT activities, respectively, than those with the major haplotype. BMI, waist circumferences, serum glucose concentrations, and blood pressure interacted with the haplotype for NAFLD risk. We also found that a high carbohydrate intake and a dietary pattern characterized by high noodle and meat consumption significantly interacted with the minor haplotype to increase the risk of NAFLD. We hypothesized that the high incidence of NAFLD among Koreans, despite a relatively low incidence of obesity, might be due to genetic factors and perhaps their interactions with dietary patterns. The hypothesis was accepted since this study confirmed that participants with the minor allele of the haplotype in the 22q13 loci had a higher NAFLD risk that was exacerbated by high intakes of carbohydrates and a dietary pattern characterized by high noodle and meat consumption.

中文翻译：

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高碳水化合物和富含面条/肉类的饮食模式与 22q13 基因座中的次要单倍型相互作用，以增加其与韩国人非酒精性脂肪性肝病风险的关联

尽管肥胖率很低，但非酒精性脂肪肝 (NAFLD) 在亚洲人中很普遍。我们假设 22q13 基因座中遗传变异的单倍型与非酒精性脂肪肝 (NAFLD) 有很强的关联，可以通过全基因组关联研究确定，生活方式可能与单倍型相互作用。我们在来自 KoGES 研究的大型城市医院队列中测试了中老年人的假设。被诊断患有脂肪肝但每天分别消耗超过 40 和 30 克乙醇的男性和女性被排除在外。产生了来自影响 NAFLD 风险的 22q13 基因座的选定 SNP 的单倍型。在 27374 名参与者中，1486 人（5.4%）被诊断出患有 NAFLD。LARGE_rs240072, RBFOX2_rs11089778, TRIOBP_rs12628603, PNPLA3_rs738409, 22q13 基因座中的 PARVB_rs2073080 和 PARVB_rs2073080 被包含在单倍型中。具有次要单倍型的参与者的 NAFLD 风险和血清 AST 和 ALT 活性分别比具有主要单倍型的参与者高 1.8、2.3 和 1.8 倍。BMI、腰围、血清葡萄糖浓度和血压与 NAFLD 风险的单倍型相互作用。我们还发现，高碳水化合物摄入量和以高面条和肉类摄入为特征的饮食模式与次要单倍型显着相互作用，从而增加了 NAFLD 的风险。我们假设韩国人中 NAFLD 的高发病率，尽管肥胖发生率相对较低，但可能是由于遗传因素及其与饮食模式的相互作用。