Implant associated infections are still key problem in surgery. In the present study, the combination of a magnetic implant with administered magnetic nanoporous silica nanoparticles as potential drug carriers was examined in mice in dependence of local infection and macrophages as influencing factors. Four groups of mice (with and without implant infection and with and without macrophage depletion) received a magnet on the left and a titanium control on the right hind leg. Then, fluorescent nanoparticles were administered and particle accumulations at implant surfaces and in inner organs as well as local tissue reactions were analyzed. Magnetic nanoparticles could be found at the surfaces of magnetic implants in different amounts depending on the treatment groups and only rarely at titanium surfaces. Different interactions of magnetic implants, particles, infection and surrounding tissues occurred. The general principle of targeted accumulation of magnetic nanoparticles could be proven.

种植体相关感染仍然是手术中的关键问题。在本研究中，根据局部感染和巨噬细胞作为影响因素，在小鼠中检查了磁性植入物与作为潜在药物载体的磁性纳米多孔二氧化硅纳米粒子的组合。四组小鼠（有和没有植入物感染以及有和没有巨噬细胞耗竭）在左侧接受磁铁，在右后腿接受钛对照。然后，施用荧光纳米颗粒并分析植入物表面和内部器官中的颗粒积累以及局部组织反应。根据治疗组的不同，在磁性植入物的表面可以发现不同数量的磁性纳米颗粒，并且很少在钛表面发现磁性纳米颗粒。磁性植入物的不同相互作用，颗粒、感染和周围组织发生。可以证明磁性纳米粒子靶向积累的一般原理。