The targeted drug release at tumor cells while sparing normal cells is a huge challenge. Core-shell magnetoelectric (ME) nanoparticles have addressed this problem using shape-dependent magneto-electric attributes. The colloidally stable, core-shell cobalt ferrite@barium titanate (CFO@BTO) ME nanoparticles (NPs) used for in vitro study were synthesized using sonochemical method. The structural characteristics and core-shell morphology were analyzed by X-ray Diffraction (XRD) and Transmission Electron Microscopy (TEM) respectively. Further magnetic and exchange coupling between two phases of ME nanostructures were studied at room temperature. Colloidal stability was studied in different suspension solutions (Water, SBB, PBS, and DMEM) using dynamic light scattering. Subsequently, the synthesized nanoparticles were functionalized with anticancer drugs including doxorubicin and methotrexate up to 80% via (EDC) chemistry. In vitro cytotoxicity studies carried out on human hepatocellular carcinoma (HepG2) and human malignant melanoma (HT144), cells validated the magneto-electric property of CFO@BTO nano-carriers in the presence of external magnetic field (5 mT), with significantly enhanced cytotoxicity when compared to free drugs and without field replicates. The resulted IC₅₀ values ranging from 5.3–7.3 μg/ml compared to 30.1–43.1 μg/ml in the absence of a magnetic field also confirmed the involved physical attributes of magnetoelectric nanostructures. The fluorescent microscopy results also indicated the increased apoptosis in magnetic field-assisted samples. Finally, hemolysis assay indicated the suitability of CFO@BTO nano-carriers for intravenous applications at IC₅₀ concentration.

在保留正常细胞的同时靶向释放肿瘤细胞是一个巨大的挑战。核-壳磁电（ME）纳米粒子已使用形状相关的磁电属性解决了这个问题。该胶体稳定的，核-壳钴铁氧体@钛酸钡（CFO @ BTO）ME纳米粒子用于（NPS）体外研究是用声化学方法合成的。分别通过X射线衍射（XRD）和透射电子显微镜（TEM）分析了结构特征和核-壳形态。在室温下研究了ME纳米结构的两相之间的进一步的磁和交换耦合。使用动态光散射在不同的悬浮液（水，SBB，PBS和DMEM）中研究了胶体稳定性。随后，通过（EDC）化学方法将合成的纳米颗粒用抗癌药（包括阿霉素和甲氨蝶呤）进行功能化，最高可达80％。体外对人类肝细胞癌（HepG2）和人类恶性黑色素瘤（HT144）进行了细胞毒性研究，细胞在存在外部磁场（5 mT）的情况下验证了CFO @ BTO纳米载体的磁电特性，当细胞毒性显着增强时与免费药物相比，没有现场重复。所产生的IC ₅₀值范围为5.3–7.3μg/ ml，而在没有磁场的情况下为30.1–43.1μg/ ml，也证实了磁电纳米结构的相关物理属性。荧光显微镜结果还表明磁场辅助样品中细胞凋亡增加。最后，溶血试验表明，CFO @ BTO纳米载体在IC ₅₀浓度下适用于静脉内应用。