Considering the inferior mechanical properties of the current bioresorbable polymers, a novel bioresorbable magnesium-reinforced polylactide (PLA) membrane was designed for the application in critical defect sites in guided bone/tissue regeneration. The PLA-FAZ91 membrane was fabricated by combining two PLA membranes with a fluoride-coated AZ91 (9 wt% Al, 1 wt% Zn) (FAZ91) magnesium alloy core by hot pressing. A combined double-layered PLA membrane was used as the control group. A three-point bending test was performed to compare their maximum load and stiffness. Samples were immersed in the HBSS for 20 weeks, and their weight loss percentages were recorded, and a three-point bending test was performed after immersion. An ion release test was performed by immersing samples in the HBSS for 4 weeks and determining the pH and ion concentrations of the HBSS. Cell viability was tested by culturing pre-osteoblast cells with sample extracts in the culture medium obtained from degraded samples. As a result, PLA-FAZ91 showed a significantly higher maximum load and stiffness than those of the non-reinforced PLA membrane. The weight loss of PLA-FAZ91 was much faster, as FAZ91 showed major degradation and was completely degraded after 16–20 weeks of immersion. The degradation of the PLA wrap was accelerated by FAZ91. The mechanical superiority of PLA-FAZ91 over PLA endured for at least 3 weeks during immersion. The pH, magnesium- and fluoride-ion concentration in the PLA-FAZ91 group increased at an appropriate rate. The cell viability was not adversely affected by the addition of FAZ91 to PLA. Therefore, the bioresorbable magnesium-reinforced PLA membrane has the potential to be used as a good alternative to pure PLA membrane in guided bone/tissue regeneration.

考虑到当前生物可吸收聚合物的机械性能较差，设计了一种新型生物可吸收镁增强聚乳酸（PLA）膜，用于引导骨/组织再生的关键缺损部位。PLA-FAZ91膜是通过热压将两个PLA膜与涂有氟化物的AZ91（9 wt％Al，1 wt％Zn）（FAZ91）镁合金芯组合而成。合并的双层PLA膜用作对照组。进行了三点弯曲测试，以比较它们的最大载荷和刚度。将样品浸入HBSS中20周，记录其失重百分比，浸入后进行三点弯曲试验。通过将样品浸入HBSS中4周并确定HBSS的pH和离子浓度来进行离子释放测试。通过在从降解样品获得的培养基中将样品提取物与成骨细胞一起培养来测试细胞活力。结果，PLA-FAZ91的最大载荷和刚度明显高于非增强PLA膜。PLA-FAZ91的重量损失要快得多，因为FAZ91表现出严重的降解作用，并且在浸泡16-20周后完全降解。FAZ91加速了PLA包装材料的降解。在浸泡过程中，PLA-FAZ91相对于PLA的机械优势至少持续了3周。PLA-FAZ91组的pH，镁离子和氟离子浓度以适当的速率增加。向PLA添加FAZ91不会对细胞活力产生不利影响。因此，可生物吸收的镁增强的PLA膜有潜力在引导的骨/组织再生中用作纯PLA膜的良好替代品。