Jasminum is an important genus in the olive family (Oleaceae), comprising about 200 species distributed all over the world. In the current study, the methanolic extract of Jasminum grandiflorum subsp. floribundum aerial parts and its respective fractions; dichloromethane and n-butanol fractions were analyzed using ultra-performance liquid chromatography coupled to high resolution mass (UPLC-HRMS) for profiling and characterization of the plant metabolites. More than seventy metabolites were identified belonging to different classes including phenolic acids, flavonoids, secoiridoids, iridoids, lignans, fatty acids, and triterpenes. The samples were also assessed for their angiotensin-I-converting enzyme (ACE) and renin inhibitory activity along with their antioxidant potential using five complementary assays: TAC (total antioxidant capacity), DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid), FRAP (ferric reducing antioxidant power) and iron reducing power. The results revealed that the n-butanol fraction showed a potent ACE and renin inhibition as compared to Lisinopril and Aliskiren standard drugs (24.66 ± 2.41 ng/mL vs. 18.37 ± 1.21 ng/mL and 141.14 ± 5.28 ng/mL vs. 447.87 ± 3.2 ng/mL, respectively) and also a strong antioxidant activity. Interestingly, the secoiridoids, dominated metabolites detected in the n-butanol fraction, revealed the potential of them for management of the hypertension diseases. The total extract and fractions were also standardized using HPLC analysis of the major secoiridoid glycoside; oleuropein. Finally, J. grandiflorum standardized extract could be considered as a target for further studies to discover a new therapeutic anti-hypertensive drug.

茉莉是橄榄科（油菜科）的重要属，包括分布在世界各地的约200种。在当前的研究中，茉莉茉莉花亚种的甲醇提取物。鸢尾属植物地上部分及其各个部分；二氯甲烷和n使用超高效液相色谱仪和高分辨率质量（UPLC-HRMS）联用分析丁醇级分，以分析和表征植物代谢产物。鉴定出超过70种代谢物，它们属于不同的类别，包括酚酸，类黄酮，secoiridoids，iridoids，木脂素，脂肪酸和三萜。还使用五种互补测定法评估了样品的血管紧张素-I转换酶（ACE）和肾素抑制活性以及其抗氧化能力：TAC（总抗氧化能力），DPPH（1,1-二苯基-2-吡啶并肼基）， ABTS（2,2'-叠氮基-双-3-乙基苯并噻唑啉-6-磺酸），FRAP（铁还原抗氧化剂）和铁还原剂。结果表明，ñ相比于赖诺普利和阿利吉仑标准药物（24.66±2.41毫微克/毫升VS丁醇馏分表现出潜在的ACE和肾素抑制。 18.37±1.21 ng / mL和141.14±5.28毫微克/毫升与447.87±3.2纳克/毫升，分别），还具有很强的抗氧化活性。有趣的是，在正丁醇馏分中检测到的主要代谢产物secrididoids揭示了它们在控制高血压疾病中的潜力。总提取物和馏分也使用主要的类蛇药苷的HPLC分析进行了标准化。橄榄苦苷。最后，大花菊标准化提取物可以被认为是进一步研究发现新的抗高血压药物的目标。