Learning changes the activity of neurons across multiple brain regions, but the significance of this distributed organization remains poorly understood, owing in part to the difficulty of observing brain-wide activity patterns in commonly used mammalian model systems. This review discusses the promise of using the small and optically accessible nervous system of larval zebrafish to study the brain-wide networks that encode experience. I discuss the opportunities and challenges of studying learning and memory in the larval zebrafish, the lessons learned from recent studies of brain-wide imaging during experience-dependent behavior, and the potential for using zebrafish neurotechnology to understand the physiological principles and behavioral significance of distributed memory networks.

学习改变了多个大脑区域神经元的活动，但这种分布式组织的重要性仍然知之甚少，部分原因是在常用的哺乳动物模型系统中观察全脑活动模式很困难。这篇综述讨论了利用斑马鱼幼虫的小型且光学可访问的神经系统来研究编码经验的全脑网络的前景。我讨论了研究斑马鱼幼虫学习和记忆的机遇和挑战，从最近的经验依赖行为全脑成像研究中吸取的教训，以及使用斑马鱼神经技术来理解分布式神经网络的生理原理和行为意义的潜力。记忆网络。