Acoustic nanodrops are designed to vaporize into ultrasound-responsive microbubbles, which presents certain challenges nonexistent for conventional nano-emulsions. The requirements of biocompatibility, vaporizability and colloidal stability has focused research on perfluorocarbons (PFCs). Shorter PFCs yield better vaporizability via their lower critical temperature, but they also dissolve more easily owing to their higher vapor pressure and solubility. Thus, acoustic nanodrops have required a tradeoff between vaporizability and colloidal stability in vivo. The recent advent of vaporizable endoskeletal droplets, which are both stable and vaporizable, may have solved this problem. The purpose of this review is to justify this premise by pointing out the beneficial properties of acoustic nanodrops, providing an analysis of vaporization and dissolution mechanisms, and reviewing current biomedical applications.

声学纳米液滴旨在汽化成超声波响应微泡，这提出了传统纳米乳液不存在的某些挑战。生物相容性、蒸发性和胶体稳定性的要求已成为全氟化碳（PFC）的研究重点。较短的 PFC 通过其较低的临界温度产生更好的蒸发性，但由于其较高的蒸气压和溶解度，它们也更容易溶解。因此，声学纳米滴需要在体内蒸发性和胶体稳定性之间进行权衡。最近出现的可蒸发内骨骼液滴既稳定又可蒸发，可能已经解决了这个问题。本综述的目的是通过指出声纳米滴的有益特性、提供汽化和溶解机制的分析以及回顾当前的生物医学应用来证明这一前提。