Combination chemotherapy is an effective way to improve the therapeutic efficiency in anticancer treatment. Herein, we synthesized a novel amphiphilic triblock copolymer via a two-step ring-opening polymerization (ROP) followed by post-modification. Doxorubicin (DOX) was encapsulated into the copolymeric micelles through hydrophobic interactions, cisplatin (CDDP) was employed to in situ crosslink the interface of DOX-loaded micelles through Pt-carboxyl coordination interaction. The CDDP-mediated crosslinking improved the stability of the micelles and also reduced the release of DOX at physiological pH. After being taken up into the endosome/lysosome, the low environmental pH weakened the Pt-carboxyl coordination interactions, resulting in the destruction of the micelles and the release of CDDP and DOX. Moreover, these micelles loaded with dual drugs enabled a synergistic anticancer effect, showing promise as a potential drug delivery platform for cancer therapy.

联合化疗是提高抗癌治疗效率的有效途径。本文中，我们通过两步开环聚合（ROP），然后进行后修饰，合成了一种新型的两亲性三嵌段共聚物。阿霉素（DOX）通过疏水相互作用被包裹在共聚物胶束中，顺铂（CDDP）用于原位通过Pt-羧基配位相互作用使DOX负载胶束的界面交联。CDDP介导的交联提高了胶束的稳定性，还减少了在生理pH下DOX的释放。低环境pH吸收到内体/溶酶体中后，削弱了Pt-羧基配位相互作用，导致胶束破坏以及CDDP和DOX释放。此外，这些载有双重药物的胶束具有协同的抗癌作用，显示出有望作为癌症治疗的潜在药物递送平台。