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Differential effect of Interferon-alpha treatment on AEA and 2-AG levels
Brain, Behavior, and Immunity ( IF 8.8 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.bbi.2020.08.024
Zuzanna Zajkowska 1 , Alessandra Borsini 1 , Naghmeh Nikkheslat 1 , Alice Russell 1 , Graziella F Romano 1 , Simona Tomassi 1 , Nilay Hepgul 1 , Daniel Forton 2 , Kosh Agarwal 3 , Matthew Hotopf 4 , Valeria Mondelli 4 , Patricia Zunszain 1 , Carmine M Pariante 4
Affiliation  

Highlights • AEA and 2-AG play part in different stages of IFN-α induced immune response.• AEA might be acting in the immunoregulation of chronic inflammation.• 2-AG may be involved in the initial stages of inflammatory response.• Targeting eCB signalling may be of interest as an anti-inflammatory treatment.

中文翻译:


干扰素-α 治疗对 AEA 和 2-AG 水平的不同影响



亮点 • AEA 和 2-AG 在 IFN-α 诱导的免疫反应的不同阶段发挥作用。• AEA 可能在慢性炎症的免疫调节中发挥作用。• 2-AG 可能参与炎症反应的初始阶段。• 靶向 eCB信号传导作为抗炎治疗可能会引起人们的兴趣。
更新日期:2020-11-01
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