Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort,Brain, Behavior, and Immunity

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Association of maternal and infant inflammation with neurodevelopment in HIV-exposed uninfected children in a South African birth cohort
Brain, Behavior, and Immunity ( IF 8.8 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.bbi.2020.08.021
Tatum Sevenoaks ₁ , Catherine J Wedderburn ₂ , Kirsten A Donald ₃ , Whitney Barnett ₄ , Heather J Zar ₅ , Dan J Stein ₆ , Petrus J W Naudé ₇

Affiliation

Department of Psychiatry and Mental Health, University of Cape Town, South Africa.
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa.
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa.
Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa; MRC Unit on Child and Adolescent Health, University of Cape Town, South Africa.
Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa; SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, University of Cape Town, South Africa.
Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Neuroscience Institute, University of Cape Town, South Africa.

Highlights • Inflammatory markers were lower in mothers living with HIV.• Inflammatory markers were lower in HIV-exposed uninfected infants and children.• Early life immune markers predicted impaired motor function at 2 years of age.

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