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QTL detection in a pedigreed breeding population of diploid potato
Euphytica ( IF 1.6 ) Pub Date : 2020-08-26 , DOI: 10.1007/s10681-020-02674-y
George Korontzis , Marcos Malosetti , Chaozhi Zheng , Chris Maliepaard , Han A. Mulder , Pim Lindhout , Roel F. Veerkamp , Fred A. van Eeuwijk

Diploid hybrid potato breeding is emerging as an alternative to breeding tetraploid potato clones. The development of diploid breeding varieties involves recent, shallow pedigrees with a limited number of founders. Within this context, alternative QTL detection methodologies should be considered to enable identification of relevant QTLs and characterize the founders of the pedigree. To that end, we are using a dataset of multiple diploid potato F3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {F}_3$$\end{document} families under selection derived by a cross between an inbred Solanum chacoense and an outbred diploid Solanum tuberosum, and identify QTLs for tuber fresh weight. We used three methods for QTL detection: (1) a Genome Wide Association Study model, (2) a linkage approach tailored to the population under study and (3) a more general approach for modelling multiallelic QTLs in complex pedigrees using identity-by-descent (IBD) probabilities. We show that all three approaches enable detection of QTLs in the population under study, but the method that makes better use of IBD information has a more direct and detailed interpretation by linking QTL alleles to the founders.

中文翻译:

一个二倍体马铃薯亲本育种群体的QTL检测

二倍体杂交马铃薯育种正在成为育种四倍体马铃薯克隆的替代方法。二倍体育种品种的开发涉及近期的浅谱系,创始人数量有限。在此背景下,应考虑替代 QTL 检测方法,以识别相关 QTL 并确定谱系创始人的特征。为此,我们使用了多个二倍体马铃薯 F3\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{ 的数据集mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\hbox {F}_3$$\end{document} 家庭在选择下由自交茄属和远交的二倍体马铃薯,并确定块茎鲜重的 QTL。我们使用了三种 QTL 检测方法:(1) 全基因组关联研究模型,(2) 针对研究人群量身定制的连锁方法,以及 (3) 一种更通用的方法,用于对复杂谱系中的多等位基因 QTL 进行建模。下降 (IBD) 概率。我们表明,所有三种方法都可以在研究的人群中检测 QTL,但是通过将 QTL 等位基因与创建者联系起来,更好地利用 IBD 信息的方法具有更直接和详细的解释。
更新日期:2020-08-26
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