For species that have been extirpated from parts of their range, conservation managers often reintroduce individuals to these areas in hopes of restoring populations to pre-decline conditions. Coho salmon (Oncorhynchus kisutch) have been extirpated since the early 1900s in the interior reaches of the Columbia River watershed. Starting in the late 1990s, the Columbia River Treaty tribes were successful in starting a re-introduction program that has established an upper Columbia River Coho salmon stock. Fish are preferentially selected for broodstock to incorporate naturally occurring phenotypic characteristics to facilitate local adaptation. On the Wenatchee River in Washington, broodstock are preferentially selected at a lower and upper river dam, however, only ~ 32% of fish successfully ascend a 15 km high-gradient reach to the upper river dam. Fish that successfully ascend the reach generally arrive early in the season and have a better overall body condition. In other salmonids, phenotypic traits such as return timing has been shown to be under genetic control. To determine if there are genomic regions that underly the phenotypic traits found to impact migration success up a high-gradient reach, low-coverage whole genome re-sequencing (lcWGR) was performed on adult fish returning to the system. Genome-wide association tests revealed three genomic regions that are associated with fish return location. Results of the lcWGR suggest that candidate markers can be incorporated as a genetic screening tool during broodstock selection to preferentially breed fish that have the phenotypic characteristics that confer greater potential for steeper and longer migration distances.

对于已经从其范围的一部分中灭绝的物种，保护经理经常将个人重新引入这些地区，以期希望将种群恢复到下降之前的状况。鲑鱼（Oncorhynchus kisutch）早在1900年代初就已在哥伦比亚河流域的内部被灭绝。从1990年代后期开始，《哥伦比亚河条约》部落成功启动了一项重新引进计划，该计划建立了上部哥伦比亚河Coho鲑鱼种群。优先选择鱼类作为亲鱼，以结合自然发生的表型特征以促进局部适应。在华盛顿的韦纳奇河上，在下游河水坝和上游河水坝优先选择亲鱼，但是，只有约32％的鱼成功爬上了15公里的高梯度河段。成功提升触角的鱼通常会在季节初到达，并具有更好的整体身体状况。在其他鲑鱼中，表型性状如回头时间已显示在遗传控制之下。为了确定是否存在基因型区域，其表型性状在高梯度范围内影响迁移成功，对成年鱼返回系统进行了低覆盖率全基因组重测序（lcWGR）。全基因组关联测试揭示了三个与鱼类返回位置相关的基因组区域。lcWGR的结果表明，可以在亲鱼选择过程中将候选标记物用作遗传筛选工具，以优先繁殖具有表型特征的鱼类，这些鱼类具有更大的潜伏距离和更长的迁移距离。全基因组关联测试揭示了三个与鱼类返回位置相关的基因组区域。lcWGR的结果表明，可以在亲鱼选择过程中将候选标记物用作遗传筛选工具，以优先繁殖具有表型特征的鱼类，这些鱼类具有更大的潜伏距离和更长的迁移距离。全基因组关联测试揭示了三个与鱼类返回位置相关的基因组区域。lcWGR的结果表明，可以在亲鱼选择过程中将候选标记物用作遗传筛选工具，以优先繁殖具有表型特征的鱼类，这些鱼类具有更大的潜伏距离和更长的迁移距离。