Drug eluting 3D printed polymeric implants have great potential in orthopaedic applications since they are relatively inexpensive and can be designed to be patient specific thereby providing quality care. Fused Deposition Modeling (FDM) and Stereolithography (SLA) are among the most popular techniques available to print such polymeric implants. These techniques facilitate introducing antibiotics into the material at microscales during the manufacturing stage and subsequently, the printed implants can be engineered to release drugs in a controlled manner. However, FDM uses high temperature to melt the filament as it passes through the nozzle and SLA relies on exposure to nanoscale wavelength ultraviolet (UV) light which can adversely affect the anti-bacterial effectiveness of the antibiotics. The focus of this article is two-fold: i) Examine the effect of high temperature on the bacterial kill-effectiveness of eluted antibiotics through Polycaprolactone (PCL) based femoral implants and ii) Examine the effect of exposure to ultraviolet (UV) light on the bacterial kill-effectiveness of eluted antibiotics through femoral implants made up of a composite resin with various weight fractions of Polyethylene Glycol (PEG) and Polyethylene Glycol Diacrylate (PEGDA). Results indicate that even after exposing doxycycline, vancomycin and cefazolin at different temperatures between 20^oC and 230^oC, the antibiotics did not lose their effectiveness (kill radius of at least 0.85 cm). For doxycycline infused implants exposed to UV light, it was seen that a resin with 20 % PEGDA and 80 % PEG had the highest efficacy (1.8 cm of kill radius) and the lowest efficacy was found in an implant with 100 % PEGDA (1.2 cm of kill radius).

中文翻译：

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温度和紫外线对注入抗生素的 3D 打印植入物的细菌杀灭效果的影响。


药物洗脱 3D 打印聚合物植入物在骨科应用中具有巨大潜力，因为它们相对便宜，并且可以针对患者进行设计，从而提供优质护理。熔融沉积成型 (FDM) 和立体光刻 (SLA) 是打印此类聚合物植入物最常用的技术。这些技术有助于在制造阶段将抗生素以微尺度引入材料中，随后，打印的植入物可以被设计为以受控方式释放药物。然而，FDM 在线材通过喷嘴时使用高温来熔化线材，而 SLA 则依赖于纳米级波长紫外线 (UV) 的照射，这会对抗生素的抗菌效果产生不利影响。本文的重点有两个：i) 检查高温对基于聚己内酯 (PCL) 的股骨植入物洗脱抗生素的细菌杀灭效果的影响，以及 ii) 检查暴露于紫外线 (UV) 的影响通过股骨植入物洗脱抗生素的细菌杀灭效果，该股骨植入物由具有不同重量分数的聚乙二醇（PEG）和聚乙二醇二丙烯酸酯（PEGDA）的复合树脂制成。结果表明，即使将多西环素、万古霉素和头孢唑林暴露在20 ^℃至230 ^℃之间的不同温度下，抗生素也不会失去其有效性（杀灭半径至少为0.85厘米）。对于暴露于紫外线下的多西环素注入植入物，可以看出，含有 20% PEGDA 和 80% PEG 的树脂具有最高功效（1.8 厘米杀伤半径），而含有 100% PEGDA 的植入物（1.2 厘米杀伤半径）功效最低。杀伤半径）。