The directed differentiation of pluripotent stem cells into motor neurons is critical for the development of disease modelling and therapeutics to intervene degenerative motor neuron diseases. Cell surface receptor Cdo functions as a coreceptor for Sonic hedgehog (Shh) with Boc and Gas1 in the patterning of ventral spinal cord neurons including motor neurons. However, the discrete function of Cdo is not fully understood.

中文翻译：

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胚胎干细胞的高效运动神经元生成需要 Cdo。

多能干细胞定向分化为运动神经元对于开发疾病建模和干预退行性运动神经元疾病的疗法至关重要。细胞表面受体 Cdo 与 Boc 和 Gas1 在包括运动神经元在内的腹侧脊髓神经元模式中作为 Sonichedgehog (Shh) 的辅助受体发挥作用。然而，Cdo 的离散函数还没有被完全理解。