The HUC-HEART Trial (ClinicalTrials.gov Identifier: NCT02323477) was a controlled, prospective, phase I/II, multicenter, single-blind, three-arm randomized study of intramyocardial delivery of human umbilical cord-derived mesenchymal stromal cells (HUC-MSCs) combined with coronary artery bypass-grafting (CABG) in patients with chronic ischemic cardiomyopathy (CIC). The trial aimed to assess (i) the safety and the efficacy of cell transplantation during one-year follow-up, (ii) to compare the efficacy of HUC-MSCs with autologous bone-marrow- derived mononuclear cells (BM-MNCs) in the same clinical settings.

中文翻译：

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慢性缺血性心肌病中脐带间充质基质细胞的心肌内移植：一项对照随机临床试验（HUC-HEART 试验）。

HUC-HEART 试验（ClinicalTrials.gov 标识符：NCT02323477）是一项对照、前瞻性、I/II 期、多中心、单盲、三臂随机研究，对人脐带间充质基质细胞（HUC- MSCs）联合冠状动脉旁路移植术（CABG）治疗慢性缺血性心肌病（CIC）患者。该试验旨在评估 (i) 细胞移植在一年随访期间的安全性和有效性，(ii) 比较 HUC-MSCs 与自体骨髓来源的单核细胞 (BM-MNCs) 在相同的临床环境。