COVID-19 pandemic has brought the whole world stand still, locked down in their homes, infecting more than 8 million people, and many thousands (449,182) -have lost their lives across the globe. Due to lack of any definitive medicine or vaccine, treatment options are supportive of oxygenation, antiviral, antiretroviral drugs, antibiotics, fluid/ electrolyte, mechanical ventilation with ICU (Intensive Care Unit) support, and chloroquine/hydroxychloroquine have been tried to fight this infection. However, mortality due to severe pneumonia, ARDS (Acute Respiratory Distress Syndrome), and multiorgan failure arising from the overactive immune response (storm) mediated by cytokines remains a treatment challenge in elderly and patients with severe medical comorbidities. Recently, anti-inflammatory, angiogenic, immune-modular, and healing properties of intravenous injections of culture derived stem cells have been proposed and shown to benefits in a small number of patients with severe COVID-19 infections. Based on previous experience with other viral infections, convalescent plasma, and serum transfusion are being used as a source of neutralizing antibody/factors to minimize the effects of inflammatory cytokines in this infection. Immunotherapy with purified monoclonal antibodies and conditioned serum with a mixture of unique cytokines are also being developed. Regenerative Medicine has emerged as a crucial adjuvant tool in promoting healing and early recovery in severe COVID-19 infections and other supportive treatments.

中文翻译：

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严重冠状病毒/ COVID 19感染中再生医学的新兴治疗选择。

COVID-19大流行使整个世界停滞不前，被困在自己的家中，感染了800万人，并且成千上万（449,182）个人在全球丧生。由于缺乏任何确定性的药物或疫苗，已尝试使用治疗方法来支持氧合，抗病毒，抗逆转录病毒药物，抗生素，液体/电解质，ICU（重症监护室）支持的机械通气，并尝试使用氯喹/羟氯喹来抵抗这种感染。然而，由于严重的肺炎，ARDS（急性呼吸窘迫综合征）以及由细胞因子介导的过度免疫反应（风暴）引起的多器官衰竭所致的死亡率仍然是老年人和患有严重合并症的患者的治疗挑战。最近，抗炎，血管生成，免疫调节，已经提出了静脉注射培养物衍生的干细胞的治疗和治愈特性，并显示出对少数患有严重COVID-19感染的患者有益。根据其他病毒感染的先前经验，恢复性血浆和血清输血被用作中和抗体/因子的来源，以最大程度地减少这种感染中炎性细胞因子的影响。也正在开发使用纯化的单克隆抗体和条件血清以及独特细胞因子混合物的免疫疗法。再生医学已成为在严重COVID-19感染和其他支持治疗中促进愈合和早期恢复的重要辅助工具。