Recent advances in cobalt-catalyzed allylic functionalization.,Organic & Biomolecular Chemistry

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Recent advances in cobalt-catalyzed allylic functionalization.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-25 , DOI: 10.1039/d0ob01581d
Jun-Fa Han ₁ , Peng Guo , Xiang-Gui Zhang , Jia-Bin Liao , Ke-Yin Ye

Affiliation

Unlike many other state-of-the-art transition-metal-catalyzed allylic substitutions, cobalt-catalyzed allylic substitution has received much less attention from synthetic chemists for a long time despite the fact that cobalt is an earth-abundant, low-cost and thus much more sustainable option as either a reagent or a catalyst in organic synthesis. Recently, there has been an upsurge in the use of cobalt catalysis in allylic functionalization reactions, including allylic substitution, nucleophilic allylation, and Heck-type allylic functionalization, to construct synthetically significant building blocks featuring a double bond available for diverse downstream synthetic manipulations. This review highlights the current development of cobalt catalysis in allylic functionalization with an in-depth discussion of the reaction scope and mechanistic insights.

中文翻译：

钴催化烯丙基官能化的最新进展。

与许多其他最先进的过渡金属催化的烯丙基取代不同，钴催化的烯丙基取代长期以来很少受到合成化学家的关注，尽管钴是一种地球丰富、低成本和因此，作为有机合成中的试剂或催化剂，更具可持续性。最近，钴催化在烯丙基官能化反应中的应用出现了热潮，包括烯丙基取代、亲核烯丙基化和 Heck 型烯丙基官能化，以构建具有可用于各种下游合成操作的双键的具有合成意义的构件。

更新日期：2020-10-15

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