Sustainable flow approaches to active pharmaceutical ingredients,Green Chemistry

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Sustainable flow approaches to active pharmaceutical ingredients
Green Chemistry ( IF 9.3 ) Pub Date : 2020-08-25 , DOI: 10.1039/d0gc02404j
Francesco Ferlin _{1,

2,

3,

4,

5} , Daniela Lanari _{3,

5,

6,

7} , Luigi Vaccaro _{1,

2,

3,

4,

5}

Affiliation

The adoption of flow conditions has been the object of growing attention from both academia and industry. The shift from batch to continuous-flow technology is very stimulating from a cultural and technological point of view. Flow technologies represent a rare opportunity for creating new proprietary access routes to complex target compounds and at the same time, they offer an incredible opportunity for increasing the efficiency of known processes that lead to modern, more sustainable future chemical production. While the general utility of flow conditions is truly convincing, its applicability assumes even greater relevance in the synthesis of Active Pharmaceutical Ingredients (APIs) due to the complexity of the targets and their high commercial value and also the highly selective chemistry involved. This review highlights the key features of flow chemistry in the synthesis of APIs by describing all the relevant literature in the field over the last 5 years, up to mid-2020. Key chemical aspects of the processes, the equipment used, and the features of the flow procedure are presented.

中文翻译：

活性药物成分的可持续流处理方法

流动条件的采用已成为学术界和工业界日益关注的对象。从文化和技术的角度来看，从批处理技术向连续流技术的转变非常令人鼓舞。流动技术为创建通往复杂目标化合物的新专有访问路线提供了难得的机会，同时，它们为提高已知流程的效率提供了令人难以置信的机会，从而导致了现代，更可持续的未来化学生产。尽管流动条件的一般用途确实令人信服，但由于靶标的复杂性及其高商业价值以及所涉及的高度选择性的化学性质，其适用性在活性药物成分（API）的合成中具有更大的相关性。这篇综述通过描述过去五年直至2020年中的该领域的所有相关文献，突出了API合成中流动化学的关键特征。介绍了过程的关键化学方面，使用的设备以及流程的功能。

更新日期：2020-09-21

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