Impact statement

There could be a close relationship between periodontal diseases (PDs) severity and Covid-19 infections. This relationship could be caused by Galectin-3-mediated increased immune response and increased viral attachment. Keeping PDs under control and maintaining rigorous oral hygiene during this troubled Covid-19 pandemic period is very important.

Patients with older age and pre-existing conditions like cardiovascular disease, hypertension, diabetes, and obesity are in the higher risk group for developing severe Covid-19 infections. The inflammatory pathways that are involved in these conditions are the same pathways that we see in periodontal diseases (PDs). This raises a significant question: Is PD a pre-existing condition that can increase the risk of developing severe Covid-19 infection? Several studies have shown that Galectins play a key role in the homeostasis of immune cells, and recently, a relationship was found between Covid-19 and Galectin-3 (Gal-3).It has been determined that an important area in the spike protein of Coronavirus-19 is almost exactly the same as the morphology of Gal-3, and these spike proteins are critical for the entry of the virus into host cells. We suspect that there is enough evidence to support a close relationship between PDs severity and Covid-19 infections. There is accumulating evidence to suggest a relationship between the severity of PD and the risk of infection with Covid-19, which requires further investigation. This relationship could be caused by Gal-3-mediated increased immune response and increased viral attachment. In this context, we want to emphasize the importance of keeping PD under control by maintaining rigorous oral hygiene during this troubled Covid-19 pandemic period. We would also like to point out the possibility that having PD may be a pre-disposition toward developing a severe Covid-19 infection.

中文翻译：

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牙周病是发生严重 Covid-19 感染的危险因素吗？Galectin-3 的潜在作用。

影响陈述

牙周病 (PD) 的严重程度与 Covid-19 感染之间可能存在密切关系。这种关系可能是由半乳糖凝集素 3 介导的免疫反应增加和病毒附着增加引起的。在这个陷入困境的 Covid-19 大流行期间，控制 PD 并保持严格的口腔卫生非常重要。

年龄较大且已有心血管疾病、高血压、糖尿病和肥胖症等疾病的患者属于发生严重 Covid-19 感染的高危人群。涉及这些病症的炎症通路与我们在牙周病 (PD) 中看到的通路相同。这提出了一个重要问题：PD 是否是一种会增加发生严重 Covid-19 感染风险的既存疾病？多项研究表明，半乳糖凝集素在免疫细胞的稳态中起着关键作用，最近，发现了 Covid-19 与半乳糖凝集素 3（Gal-3）之间的关系。 已经确定，刺突蛋白中的一个重要区域冠状病毒19的形态与Gal-3的形态几乎完全相同，这些刺突蛋白对于病毒进入宿主细胞至关重要。我们怀疑有足够的证据支持 PD 严重程度与 Covid-19 感染之间的密切关系。越来越多的证据表明 PD 的严重程度与感染 Covid-19 的风险之间存在关系，这需要进一步调查。这种关系可能是由 Gal-3 介导的免疫反应增加和病毒附着增加引起的。在这种情况下，我们想强调在这个陷入困境的 Covid-19 大流行期间通过保持严格的口腔卫生来控制 PD 的重要性。我们还想指出，患有 PD 可能是发展为严重 Covid-19 感染的先决条件。越来越多的证据表明 PD 的严重程度与感染 Covid-19 的风险之间存在关系，这需要进一步调查。这种关系可能是由 Gal-3 介导的免疫反应增加和病毒附着增加引起的。在这种情况下，我们想强调在这个陷入困境的 Covid-19 大流行期间保持严格的口腔卫生来控制 PD 的重要性。我们还想指出，患有 PD 可能是发展为严重 Covid-19 感染的先决条件。越来越多的证据表明 PD 的严重程度与感染 Covid-19 的风险之间存在关系，这需要进一步调查。这种关系可能是由 Gal-3 介导的免疫反应增加和病毒附着增加引起的。在这种情况下，我们想强调在这个陷入困境的 Covid-19 大流行期间通过保持严格的口腔卫生来控制 PD 的重要性。我们还想指出，患有 PD 可能是发展为严重 Covid-19 感染的先决条件。我们想强调在这个陷入困境的 Covid-19 大流行期间保持严格的口腔卫生来控制 PD 的重要性。我们还想指出，患有 PD 可能是发展为严重 Covid-19 感染的先决条件。我们想强调在这个陷入困境的 Covid-19 大流行期间保持严格的口腔卫生来控制 PD 的重要性。我们还想指出，患有 PD 可能是发展为严重 Covid-19 感染的先决条件。