Background

The characteristics of the hypersensitivity to auditory stimuli during the interictal period in episodic migraine are discussed. The combined use of event-related potentials, time-frequency power and phase-synchronization can provide relevant information about the time-course of sensory-attentional processing in migraine and its underlying mechanisms.

Objective

The aim of this nested case-control study was to examine these processes in young, female, episodic migraine patients interictally and compare them to controls using an active auditory oddball task.

Method

We recorded, using 20 channels, the electrophysiological brain activity of 21 women with episodic migraine without aura and 21 healthy matched controls without family history of migraine, during a novelty oddball paradigm. We collected sociodemographic and clinical data as well as scores related to disability, quality of life, anxiety and depression. We calculated behavioural measures including reaction times, hit rates and false alarms. Spectral power and phase-synchronization of oscillatory activity as well as event-related potentials were obtained for standard stimuli. For target and novel stimuli, event-related potentials were acquired.

Results

There were no significant differences at the behavioural level. In migraine patients, we found an increased phase-synchronization at the theta frequency range and a higher N1 response to standard trials. No differences were observed in spectral power. No evidence for a lack of habituation in any of the measures was seen between migraine patients and controls. The Reorienting Negativity was reduced in migraine patients as compared to controls on novel but not on target trials.

Conclusion

Our findings suggest that migraine patients process stimuli as more salient, seem to allocate more of their attentional resources to their surrounding environment, and have less available resources to reorient attention back to the main task.

中文翻译：

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发作间期发作性偏头痛中异常听觉处理的神经生理学相关性。

背景

讨论了发作性偏头痛发作间期听觉刺激超敏反应的特点。事件相关电位、时频功率和相位同步的组合使用可以提供有关偏头痛感觉-注意加工的时间过程及其潜在机制的相关信息。

客观的

这项嵌套病例对照研究的目的是在间歇期检查年轻女性发作性偏头痛患者的这些过程，并使用主动听觉古怪任务将它们与对照组进行比较。

方法

我们使用 20 个通道记录了 21 名无先兆发作性偏头痛的女性和 21 名无偏头痛家族史的健康对照，在新奇的古怪范式中的脑电生理活动。我们收集了社会人口学和临床数据以及与残疾、生活质量、焦虑和抑郁相关的分数。我们计算了行为指标，包括反应时间、命中率和误报率。获得了标准刺激的光谱功率和振荡活动的相位同步以及事件相关电位。对于目标和新刺激，获取事件相关电位。

结果

在行为层面上没有显着差异。在偏头痛患者中，我们发现 theta 频率范围内的相位同步增加，并且对标准试验的 N1 响应更高。没有观察到光谱功率的差异。在偏头痛患者和对照组之间没有发现任何措施缺乏习惯的证据。与新的而非目标试验的对照相比，偏头痛患者的重新定向消极性降低。

结论

我们的研究结果表明，偏头痛患者对刺激的处理更加显着，似乎将更多的注意力资源分配给周围环境，而将注意力重新定位回主要任务的可用资源较少。