Objective: Sepsis causes millions of deaths on a global scale annually. Activation of peptidylarginine deiminase (PAD) enzymes in sepsis causes citrullination of histones, which results in neutrophil extracellular trap formation and sepsis progression. This study evaluates pan-PAD inhibitor, Cl-amidine, in a model of lipopolysaccharide (LPS)-induced endotoxic shock in rabbits. We hypothesized that Cl-amidine would improve survival and attenuate kidney injury.

中文翻译：

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Cl-脒可提高内毒素休克兔模型的存活率并减轻肾损伤

目标：脓毒症每年在全球范围内导致数百万人死亡。脓毒症中肽基精氨酸脱亚胺酶 (PAD) 的激活会导致组蛋白瓜氨酸化，从而导致中性粒细胞胞外陷阱形成和脓毒症进展。本研究在脂多糖 (LPS) 诱导的内毒素休克模型中评估泛 PAD 抑制剂 Cl-脒。我们假设 Cl-脒可以提高生存率并减轻肾损伤。