Background: Temozolomide (TMZ) resistance is a serious hindrance in clinical chemotherapy for glioma. Circular RNA homeodomain interacting protein kinase 3 (circHIPK3) can be involved in regulating the progression of glioma, but the molecular mechanism of circHIPK3 in TMZ-resistant-glioma is completely unclear.

中文翻译：

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通过 miR-524-5p/KIF2A 介导的 PI3K/AKT 通路调节细胞行为，敲低 circHIPK3 促进神经胶质瘤中的替莫唑胺敏感性

背景：替莫唑胺（TMZ）耐药是胶质瘤临床化疗的一个严重障碍。环状RNA同源域相互作用蛋白激酶3（circHIPK3）可参与调节胶质瘤的进展，但circHIPK3在TMZ耐药胶质瘤中的分子机制尚不清楚。