Here we show an interplay between the structures present in ionization tracks and nucleocapsid RNA structural biology, using fast ion beam inactivation of the severe acute respiratory syndrome coronavirus (SARS-CoV) virion as an example. This interplay is one of the key factors in predicting dose-inactivation curves for high energy ion beam inactivation of virions. We also investigate the adaptation of well-established cross-section data derived from radiation interactions with water to the interactions involving the components of a virion, going beyond the density-scaling approximation developed previously. We conclude that solving one of the grand challenges of structural biology - the determination of RNA tertiary/quaternary structure structure - is intimately linked to predicting ion-beam inactivation of viruses and that the two problems can be mutually informative. Indeed, our simulations show that fast ion beams have a key role to play in elucidating RNA tertiary/quaternary structure.

中文翻译：

---

病毒的快速离子束灭活，其中辐射径迹结构符合RNA结构生物学。

在这里，我们以严重急性呼吸系统综合症冠状病毒（SARS-CoV）病毒粒子的快速离子束灭活为例，展示了电离轨道中存在的结构与核衣壳RNA结构生物学之间的相互作用。这种相互作用是预测病毒粒子高能离子束失活剂量失活曲线的关键因素之一。我们还研究了建立良好的横截面数据的适应性，该数据源自与水的辐射相互作用对涉及病毒体成分的相互作用的适应，超出了先前开发的密度比例近似。我们得出结论，解决结构生物学的重大挑战之一-确定RNA三级/四级结构的结构-与预测病毒的离子束灭活密切相关，并且这两个问题可以相互借鉴。实际上，我们的模拟表明，快速离子束在阐明RNA三级/四级结构中起着关键作用。