Raman Spectroscopy Methods to Characterize the Mechanical Response of Soft Biomaterials.,Biomacromolecules

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Raman Spectroscopy Methods to Characterize the Mechanical Response of Soft Biomaterials.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-08-24 , DOI: 10.1021/acs.biomac.0c00818
Hui Zhou ₁ , Chelsey S Simmons ₁ , Malisa Sarntinoranont ₁ , Ghatu Subhash ₁

Affiliation

Raman spectroscopy has been used extensively to characterize the influence of mechanical deformation on microstructure changes in biomaterials. While traditional piezo-spectroscopy has been successful in assessing internal stresses of hard biomaterials by tracking prominent peak shifts, peak shifts due to applied loads are near or below the resolution limit of the spectrometer for soft biomaterials with moduli in the kilo- to mega-Pascal range. In this Review, in addition to peak shifts, other spectral features (e.g., polarized intensity and intensity ratio) that provide quantitative assessments of microstructural orientation and secondary structure in soft biomaterials and their strain dependence are discussed. We provide specific examples for each method and classify sensitive Raman characteristic bands common across natural (e.g., soft tissue) and synthetic (e.g., polymeric scaffolds) soft biomaterials upon mechanical deformation. This Review can provide guidance for researchers aiming to analyze micromechanics of soft tissues and engineered tissue constructs by Raman spectroscopy.

中文翻译：

拉曼光谱法表征软生物材料的机械响应。

拉曼光谱已被广泛用于表征机械变形对生物材料微观结构变化的影响。尽管传统的压电光谱已成功通过跟踪显着的峰位移来评估硬生物材料的内应力，但由于施加的载荷而导致的峰位移接近或低于模量为千至兆帕的软生物材料的光谱仪的分辨率极限。范围。在本综述中，除了峰移动以外，还讨论了其他光谱特征（例如极化强度和强度比），这些特征可定量评估软生物材料的微观结构取向和二级结构及其应变依赖性。我们提供每种方法的具体示例，并对自然界中常见的敏感拉曼特征谱带进行分类（例如，机械变形后）和合成的（例如，聚合物支架）软生物材料。这篇综述可以为旨在通过拉曼光谱分析软组织和工程组织构造的微力学的研究人员提供指导。

更新日期：2020-09-14

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