Treatment discontinuation impact on long-term (10-years) weight gain and lipid metabolism in first-episode psychosis: results from the PAFIP-10 cohort.,International Journal of Neuropsychopharmacology

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Treatment discontinuation impact on long-term (10-years) weight gain and lipid metabolism in first-episode psychosis: results from the PAFIP-10 cohort.
International Journal of Neuropsychopharmacology ( IF 4.5 ) Pub Date : 2020-08-25 , DOI: 10.1093/ijnp/pyaa066
Javier Vázquez-Bourgon _{1,

2,

3} , Jaqueline Mayoral-van Son _{2,

4} , Marcos Gómez-Revuelta _{1,

3} , María Juncal-Ruiz _{3,

5} , Víctor Ortiz-García de la Foz ₁ , Diana Tordesillas-Gutiérrez _{1,

2,

3} , Rosa Ayesa-Arriola _{1,

2,

3} , Miquel Bioque _{2,

6} , Benedicto Crespo-Facorro _{2,

4}

Affiliation

Patients with a first episode of psychosis (FEP) are at higher risk of gaining weight and presenting metabolic disturbances, partly related to antipsychotic exposure. Previous studies suggest that treatment discontinuation might have a positive impact on weight in schizophrenia. The aim of this study is to evaluate the effect of treatment discontinuation on weight and metabolic changes in a FEP cohort.

中文翻译：

治疗中止对首发精神病患者长期（10 年）体重增加和脂质代谢的影响：来自 PAFIP-10 队列的结果。

首次发作精神病 (FEP) 的患者体重增加和出现代谢紊乱的风险较高，部分与抗精神病药物暴露有关。先前的研究表明，停止治疗可能对精神分裂症患者的体重产生积极影响。本研究的目的是评估停药对 FEP 队列中体重和代谢变化的影响。

更新日期：2020-08-25

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