The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.

当前爆发的SARS-CoV-2病毒已导致与呼吸道疾病相关的死亡率和发病率大大增加。当前正在进行巨大的努力来开发针对这种病毒的疫苗。但是，在对抗这种疾病时可以考虑采用其他方法。在其他策略中，基于结构的药物设计可能是产生针对SARS-CoV-2的特异性分子的有效方法，从而减轻感染患者的病毒负担。在这里，除了这种结构方法之外，我们还修订了几种治疗策略来对抗这种病毒威胁。此外，我们报告了ACE-2遗传多态变异体，其影响与SARS-CoV-2密切接触所涉及的残基可能与不同的感染风险相关。