The current outbreak of SARS-CoV-2 virus has caused a large increase in mortality and morbidity associated with respiratory diseases. Huge efforts are currently ongoing to develop a vaccine against this virus. However, alternative approaches could be considered in the fight against this disease. Among other strategies, structural-based drug design could be an effective approach to generate specific molecules against SARS-CoV-2, thus reducing viral burden in infected patients. Here, in addition to this structural approach, we also revise several therapeutic strategies to fight against this viral threat. Furthermore, we report ACE-2 genetic polymorphic variants affecting residues involved in close contacts with SARS-CoV-2 that might be associated to different infection risks. These analyses could provide valuable information to predict the course of the disease.

当前 SARS-CoV-2 病毒的爆发已导致与呼吸道疾病相关的死亡率和发病率大幅增加。目前正在付出巨大努力来开发针对这种病毒的疫苗。然而，可以考虑采用替代方法来对抗这种疾病。除其他策略外，基于结构的药物设计可能是生成针对 SARS-CoV-2 的特定分子的有效方法，从而减少感染患者的病毒负担。在这里，除了这种结构方法之外，我们还修改了几种治疗策略来对抗这种病毒威胁。此外，我们报告了影响与 SARS-CoV-2 密切接触的残基的 ACE-2 遗传多态性变异，这些变异可能与不同的感染风险相关。这些分析可以提供有价值的信息来预测疾病的进程。