Resting-state EEG microstates are brief (50–100 ms) periods, in which the spatial configuration of scalp global field power remains quasi-stable before rapidly shifting to another configuration. Changes in microstate parameters have been described in patients with psychotic disorders. These changes have also been observed in individuals with a clinical or genetic high risk, suggesting potential usefulness of EEG microstates as a biomarker for psychotic disorders. The present study aimed to investigate the potential of EEG microstates as biomarkers for psychotic disorders and future transition to psychosis in patients at ultra-high-risk (UHR). We used 19-channel clinical EEG recordings and orthogonal contrasts to compare temporal parameters of four normative microstate classes (A–D) between patients with first-episode psychosis (FEP; n = 29), UHR patients with (UHR-T; n = 20) and without (UHR-NT; n = 34) later transition to psychosis, and healthy controls (HC; n = 25). Microstate A was increased in patients (FEP & UHR-T & UHR-NT) compared to HC, suggesting an unspecific state biomarker of general psychopathology. Microstate B displayed a decrease in FEP compared to both UHR patient groups, and thus may represent a state biomarker specific to psychotic illness progression. Microstate D was significantly decreased in UHR-T compared to UHR-NT, suggesting its potential as a selective biomarker of future transition in UHR patients.

静止状态的脑电图微状态是短暂的（50–100 ms）周期，在此期间，头皮全局场功率的空间配置在快速转变为其他配置之前保持准稳定。精神病患者已描述了微状态参数的变化。在具有临床或遗传高风险的个体中也观察到了这些变化，表明脑电图微状态作为精神病性疾病的生物标志物的潜在用途。本研究旨在调查超高风险（UHR）患者中脑电图微状态作为精神疾病的生物标志物以及将来向精神病过渡的生物标志物的潜力。我们使用19通道临床脑电图记录和正交对比来比较首发精神病（FEP）患者之间四个规范微状态类别（AD）的时间参数。n  = 29），患有（UHR-T; n  = 20）和不患有（UHR-NT; n  = 34）的UHR患者后来过渡到精神病和健康对照（HC; n  = 25）。与HC相比，患者的微状态A增加（FEP和UHR-T和UHR-NT），表明一般精神病理学是非特异性状态生物标志物。与两个UHR患者组相比，微状态B的FEP降低，因此可能代表了一种针对精神疾病进展的状态生物标志物。与UHR-NT相比，UHR-T中的微状态D显着降低，表明其作为UHR患者未来过渡的选择性生物标记物的潜力。