Remodeling Tumor Microenvironment by Multifunctional Nanoassemblies for Enhanced Photodynamic Cancer Therapy,ACS Materials Letters

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Remodeling Tumor Microenvironment by Multifunctional Nanoassemblies for Enhanced Photodynamic Cancer Therapy
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-08-24 , DOI: 10.1021/acsmaterialslett.0c00259
Chen Liang _{1,

2} , Xinglin Zhang ₁ , Mengsu Yang ₂ , Wenjun Wang ₃ , Peng Chen ₄ , Xiaochen Dong _{1,

5}

Affiliation

Photodynamic therapy (PDT) is a clinically implemented modality to tackle intractable diseases, including cancer. Nevertheless, its efficacy is largely compromised by some resistance factors from the complex tumor microenvironment (TME) with various biological barriers. Inspiringly, recent development in nanotechnology has revitalized photodynamic cancer therapy based on rationally designed nanoplatforms that can boost PDT through remodeling TME. Here, we first provide an overview of the microenvironment in solid tumors and the PDT-resistance factors therein. On this basis, we discuss strategies to design multifunctional nanoassemblies and underlying working mechanisms to enhance photodynamic cancer therapy by modulating tumor vasculatures, extracellular matrix, hypoxia, antioxidant defense, and immune suppression. Finally, we highlight the potential and challenges in this burgeoning research field.

中文翻译：

通过多功能纳米组件重塑肿瘤微环境，以增强光动力癌症治疗。

光动力疗法（PDT）是临床上用于治疗包括癌症在内的难治性疾病的方法。然而，其功效在很大程度上受到来自具有多种生物屏障的复杂肿瘤微环境（TME）的一些耐药因素的影响。令人鼓舞的是，基于合理设计的纳米平台，纳米技术的最新发展已振兴了光动力癌症疗法，该平台可通过重塑TME来增强PDT。在此，我们首先概述实体瘤的微环境及其中的PDT抗性因子。在此基础上，我们讨论了设计多功能纳米组件的策略和潜在的工作机制，以通过调节肿瘤脉管系统，细胞外基质，缺氧，抗氧化剂防御和免疫抑制来增强光动力癌症治疗。最后，

更新日期：2020-10-05

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