Coronavirus Disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a severe public health problem with a high rate of morbidity and mortality. A mounting number of clinical investigations illustrate that COVID-19 patients suffer from neurologic conditions in addition to respiratory symptoms. In a recent article, Yuen and colleagues present the first experimental evidence of SARS-CoV-2 infection in the human central nervous system using induced pluripotent stem cells (iPSCs)-derived platform including human neural progenitor cells, neurospheres, and three-dimensional brain organoids (Yuen, K.Y., and Huang, J.D. et al. (2020) Cell Res. DOI: 10.1038/s41422-020-0390-x).

中文翻译：

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iPSC 衍生平台：探测 SARS-CoV-2 向神经性的可行工具。

由新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的2019冠状病毒病（COVID-19）已成为一个严重的公共卫生问题，发病率和死亡率很高。越来越多的临床研究表明，COVID-19 患者除了呼吸道症状外，还患有神经系统疾病。在最近的一篇文章中，Yuen 及其同事使用诱导多能干细胞 (iPSC) 衍生平台（包括人类神经祖细胞、神经球和三维大脑）首次展示了人类中枢神经系统中 SARS-CoV-2 感染的实验证据类器官（Yuen, KY 和 Huang, JD 等人 ( 2020 ) Cell Res. DOI: 10.1038/s41422-020-0390-x）。