Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers,ACS Biomaterials Science & Engineering

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Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-08-24 , DOI: 10.1021/acsbiomaterials.0c00713
Antonio R. Cerullo _{1,

2,

3} , Tsoi Ying Lai ₂ , Bassem Allam ₄ , Alexander Baer ₅ , W. Jon P. Barnes ₆ , Zaidett Barrientos ₇ , Dimitri D. Deheyn ₈ , Douglas S. Fudge ₉ , John Gould ₁₀ , Matthew J. Harrington ₁₁ , Mandë Holford _{1,

3,

12,

13,

14} , Chia-Suei Hung ₁₅ , Gaurav Jain ₉ , Georg Mayer ₅ , Mónica Medina ₁₆ , Julian Monge-Nájera ₇ , Tanya Napolitano _{1,

3} , Emmanuelle Pales Espinosa ₄ , Stephan Schmidt ₁₇ , Eric M. Thompson _{18,

19} , Adam B. Braunschweig _{1,

2,

3,

13}

Affiliation

The PhD Program in Biochemistry, Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States
The Advanced Science Research Center, Graduate Center of the City University of New York, 85 St. Nicholas Terrace, New York, New York 10031, United States
Department of Chemistry and Biochemistry, Hunter College, 695 Park Avenue, New York, New York 10065, United States
School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York 11794-5000, United States
Department of Zoology, Institute of Biology, University of Kassel, Heinrich-Plett-Strasse 40, 34132 Kassel, Germany
Centre for Cell Engineering, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.
Laboratorio de Ecología Urbana, Universidad Estatal a Distancia, Mercedes de Montes de Oca, San José 474-2050, Costa Rica
Marine Biology Research Division-0202, Scripps Institute of Oceanography, UCSD, 9500 Gilman Drive, La Jolla, California 92093, United States
Schmid College of Science and Technology, Chapman University, 1 University Drive, Orange, California 92866, United States
School of Environmental and Life Sciences, University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada
Department of Invertebrate Zoology, The American Museum of Natural History, New York, New York 10024, United States
The PhD Program in Chemistry, Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States
The PhD Program in Biology, Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States
Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Dayton, Ohio 45433, United States
Department of Biology, Pennsylvania State University, 208 Mueller Lab, University Park, Pennsylvania 16802, United States
Institute of Organic and Macromolecular Chemistry, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany
Sars Centre for Marine Molecular Biology, Thormøhlensgt. 55, 5020 Bergen, Norway
Department of Biological Sciences, University of Bergen, N-5006 Bergen, Norway

The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the hierarchical architectures, material properties, and genetics of mucus remain. Here, we summarize what is known about secreted mucus structure, describe the work of research groups throughout the world who are investigating various animal mucuses, and relate how these studies are revealing new mucus properties and the relationships between mucus hierarchical structure and hydrogel function. Finally, we call for a more systematic approach to studying animal mucuses so that data sets can be compared, omics-style, to address unanswered questions in the emerging field of mucomics. One major result that we anticipate from these efforts is design rules for creating new materials that are inspired by the structures and functions of animal mucuses.

中文翻译：

比较动物动物学：普遍存在和研究不足的生物聚合物对功能材料的启示

分泌的动物粘液的功能非常多样，包括润滑剂，湿胶，防护屏障和矿化剂。尽管存在于所有动物中，但仍存在许多与层次结构，材料特性和粘液遗传有关的开放性问题。在这里，我们总结了关于分泌的粘液结构的已知信息，描述了全世界正在研究各种动物粘液的研究小组的工作，并关联了这些研究如何揭示新的粘液特性以及粘液分级结构与水凝胶功能之间的关系。最后，我们呼吁采用更系统的方法来研究动物粘液，以便可以以组学形式比较数据集，以解决新兴的粘液学领域中尚未解决的问题。

更新日期：2020-10-12

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