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Part—II: Utilities of active methylene compounds and heterocycles bearing active methyl or having an active methine in the formation of bioactive pyrazoles and pyrazolopyrimidines
Synthetic Communications ( IF 1.8 ) Pub Date : 2020-08-24 , DOI: 10.1080/00397911.2020.1807570
Mohamed Abdel-Megid 1, 2
Affiliation  

Abstract Common and novel synthesized active methylene compounds as well as some heterocycles bearing active methyl or having an active methine in their structures used for the syntheses of pyrazoles and pyrazolopyrimidines of expected medical and pharmaceutical importance. Many synthetic approaches were used for the syntheses of the target heterocyclic systems such as cyclocondensation reactions, ring opening-ring closure, cycloaddition, acid-, base-catalyzed reaction, intramolecular cyclization and self-condensation as well as ring-chain tautomersim has been discussed in this review. In addition, the antimicrobial activity and Mollucicidal activity of some newly synthesized pyrazoles and pyrazolopyrimidines compounds were deduced. Graphical Abstract

中文翻译:

第二部分:活性亚甲基化合物和带有活性甲基或具有活性次甲基的杂环在生物活性吡唑和吡唑并嘧啶形成中的应用

摘要 常见和新型合成的活性亚甲基化合物以及一些在其结构中带有活性甲基或具有活性次甲基的杂环,用于合成具有预期医学和药学重要性的吡唑和吡唑并嘧啶。许多合成方法用于合成目标杂环系统,如环缩合反应、开环-闭环、环加成、酸、碱催化反应、分子内环化和自缩合以及环链互变异构体已经讨论在这次审查中。此外,还推导出了一些新合成的吡唑类和吡唑并嘧啶类化合物的抗菌活性和杀软体动物活性。图形概要
更新日期:2020-08-24
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