ABSTRACT To find the molecular components with the highest underlying probability of sensitization in patients suffering from atopic dermatitis and in subgroup of patients with allergic rhinitis, asthma bronchiale and to determine whether there is some difference of sensitization in mild, moderate and severe form of AD, in patients suffering from asthma bronchiale and allergic rhinitis. The complete dermatological and allergological examination including the examination of the sensitization to molecular allergens with Multiplex ISAC testing was performed. Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years; the sensitization to molecular components was confirmed in 93% of patients. The highest observed sensitization rate was 61.0% to grass specific molecule Phl p 1, the second most frequent sensitization was 57.0% to Betulaceae-specific molecule Bet v 1. Frequently observed sensitizations were those to PR-10 proteins, NPC2 proteins family, Uteroglobin and Lipocalin. In severe form of atopic dermatitis sensitization to molecular components of NPC2 proteins family, Uteroglobin, Lipocalin and Aspergillus were recorded with a significant higher occurrence.

中文翻译：

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ISAC 多重检测——100 名特应性皮炎患者的检查结果

摘要 为了寻找特应性皮炎患者和过敏性鼻炎、支气管哮喘患者亚组中潜在致敏概率最高的分子成分，并确定轻度、中度和重度 AD 的致敏性是否存在一定差异，患有支气管哮喘和过敏性鼻炎的患者。进行了完整的皮肤病学和过敏症检查，包括使用多重 ISAC 测试检查对分子过敏原的敏感性。共检查了 100 名特应性皮炎患者——48 名男性，52 名女性，平均年龄 40.9 岁；93% 的患者证实对分子成分过敏。观察到的最高致敏率为 61.0% 对草特异性分子 Phl p 1，第二最常见的致敏是对桦木科特异性分子 Bet v 1 的 57.0%。经常观察到的致敏是对 PR-10 蛋白、NPC2 蛋白家族、子宫珠蛋白和脂质运载蛋白的致敏。在对 NPC2 蛋白家族的分子成分敏感的特应性皮炎的严重形式中，子宫珠蛋白、脂质运载蛋白和曲霉被记录为显着更高的发生率。