ABSTRACT

Introduction

Modern comprehensive studies of tumor microenvironment changes allowed scientists to develop new and more efficient strategies that will improve anticancer drug delivery on site. The tumor microenvironment, especially the dense extracellular matrix, has a recognized capability to hamper the penetration of conventional drugs. Development and co-applications of strategies aiming at remodeling the tumor microenvironment are highly demanded to improve drug delivery at the tumor site in a therapeutic prospect.

Areas covered

Increasing indications suggest that classical physical approaches such as exposure to ionizing radiations, hyperthermia or light irradiation, and emerging ones as sonoporation, electric field or cold plasma technology can be applied as standalone or associated strategies to remodel the tumor microenvironment. The impacts on vasculature and extracellular matrix remodeling of these physical approaches will be discussed with the goal to improve nanotherapeutics delivery at the tumor site.

Expert opinion

Physical approaches to modulate vascular properties and remodel the extracellular matrix are of particular interest to locally control and improve drug delivery and thus increase its therapeutic index. They are particularly powerful as adjuvant to nanomedicine delivery; the development of these technologies could have extremely widespread implications for cancer treatment.

中文翻译：

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通过物理方法重塑血管和细胞外基质，以改善肿瘤部位的药物递送。

摘要

介绍

对肿瘤微环境变化的现代综合研究使科学家能够开发新的更有效的策略，以改善现场的抗癌药物递送。肿瘤微环境，特别是致密的细胞外基质，具有公认的抑制常规药物渗透的能力。迫切需要开发和共同应用旨在重塑肿瘤微环境的策略，以改善治疗前景中在肿瘤部位的药物递送。

覆盖区域

越来越多的迹象表明，经典的物理方法，例如暴露于电离辐射，热疗或光辐照，以及新兴的声穿孔，电场或冷等离子体技术，都可以作为独立的或相关的策略来重塑肿瘤微环境。将讨论这些物理方法对脉管系统和细胞外基质重塑的影响，目的是改善纳米治疗剂在肿瘤部位的递送。

专家意见

调节血管特性和重塑细胞外基质的物理方法对于局部控制和改善药物递送并因此增加其治疗指数特别有意义。它们作为纳米药物输送的佐剂特别有效。这些技术的发展可能会对癌症治疗产生极为广泛的影响。