Abstract

The aim of the present study is to evaluate the level of contamination of breast milk (BM) by ochratoxin A, among Moroccan lactating mothers in the city of Rabat, and to identify the associated factors of exposure, also to estimate the degree of exposure of the breastfeed infant. The analysis of ochratoxin A (OTA) was accomplished by ELISA method on 82 colostrum samples. OTA was detectable (>0.08 ng/mL) in 55% of samples with a maximum concentration of 10.04 ng/mL, and the levels exceeded 0.5 ng /mL in 50 % of the samples. In addition, several factors and dietary habits affect significantly the level of OTA in the analyzed samples of breast milk including, the consumption of industrial dairy products, the frequency of consumption of canned foods, dried fruits and legumes, also the period of breast milk collection. Besides, OTA was higher than the tolerable daily intake for 49% newborns. However, these results need to be confirmed by multicenter studies to more broadly estimate the levels of exposition of Moroccan population to OTA. Furthermore, awareness campaigns are recommended to inform the public, especially pregnant women and lactating women about appropriate preventive measures to limit exposure to this mycotoxin.

摘要

本研究的目的是评估拉巴特市摩洛哥哺乳期母亲中赭曲霉毒素 A 对母乳 (BM) 的污染水平，并确定相关的接触因素，同时估计接触赭曲霉毒素 A 的程度。母乳喂养的婴儿。采用ELISA方法对82份初乳样品进行赭曲霉毒素A（OTA）的分析。OTA 在 55% 的样品中可检测到 (>0.08 ng/mL)，最大浓度为 10.04 ng/mL，并且在 50% 的样品中水平超过 0.5 ng/mL。此外，有几个因素和饮食习惯会显着影响分析的母乳样本中的 OTA 水平，包括工业乳制品的消费、罐头食品、干果和豆类的消费频率，以及母乳收集的时间。 . 除了，OTA 高于 49% 新生儿的每日可耐受摄入量。然而，这些结果需要通过多中心研究来证实，以更广泛地估计摩洛哥人口对 OTA 的暴露水平。此外，建议开展宣传活动，让公众，尤其是孕妇和哺乳期妇女了解适当的预防措施，以限制接触这种霉菌毒素。