α-ω Alkenyl-bis-S-Guanidine Thiourea Dihydrobromide Affects HeLa Cell Growth Hampering Tubulin Polymerization.,ChemMedChem

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α-ω Alkenyl-bis-S-Guanidine Thiourea Dihydrobromide Affects HeLa Cell Growth Hampering Tubulin Polymerization.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-08-25 , DOI: 10.1002/cmdc.202000544
Jessica Ceramella _{1,

2} , Annaluisa Mariconda ₃ , Camillo Rosano ₄ , Domenico Iacopetta ₁ , Anna Caruso ₁ , Pasquale Longo ₂ , Maria Stefania Sinicropi ₁ , Carmela Saturnino ₃

Affiliation

Cancer is going to be the first cause of mortality worldwide in the 21th century. It is considered a multifactorial disease that results from the combined influence of many genetic aberrations, leading to abnormal cell proliferation. As microtubules are strongly implicated in cellular growth, they represent an important target for cancer treatment. The well‐known microtubule‐targeting agents (MTAs) including paclitaxel, colchicine and vinca alkaloids are commonly used in the treatment of various cancers. However, adverse effects and drug resistance are major limitations in their clinical use.

中文翻译：

α-ω 烯基-双-S-胍硫脲二氢溴化物影响 HeLa 细胞生长，阻碍微管蛋白聚合。

癌症将成为 21 世纪世界范围内的第一大死因。它被认为是一种多因素疾病，是由许多遗传畸变的综合影响导致的，导致细胞异常增殖。由于微管与细胞生长密切相关，因此它们代表了癌症治疗的重要目标。众所周知的微管靶向剂（MTA）包括紫杉醇、秋水仙碱和长春花生物碱，常用于治疗各种癌症。然而，不良反应和耐药性是其临床使用的主要限制。

更新日期：2020-08-25

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