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REFERENCE VALUES FOR THE 12 MINUTE WALK TEST IN MCARDLE PATIENTS
Neuromuscular Disorders ( IF 2.7 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.nmd.2020.08.361
Jatin Pattni 1 , Richard Godfrey 2 , Sherryl Chatfield 1 , Suzanne Booth 1 , Rosaline Quinlivan 3
Affiliation  

The maximum distance achieved on a modified 12 min walk test (12MWT) is a well-established measure in McArdle disease glycogen storage disease type V (GSDV). Age, height, body mass and gender are known predictors of walking distance in other patient groups. Reference values to correct for these predictors are necessary for comparisons between individuals. To date, there has not been a systematic investigation of these predictors in the 12MWT in GSDV. This study explores the contribution of these predictors on distance achieved in GSDV. Data, included maximum distance walked, age, gender, height and body mass, was collected from 103 GSDV patients who underwent 12MWT between 2011 and 2017. Analysis showed a significant correlation between distance achieved and height, age, body mass and gender. Multiple linear regression analysis revealed a model accounting for 29.7% of variance (R = 0.545, R2 0.297, adjusted R2 0.269). Gender was not significant after height, age and body mass were entered into the regression analysis. This is the first study to report the contribution of non-disease related factors on distance achieved on the 12MWT in the GSDV population. The reference values generated will allow for improved monitoring and assessment of GSDV patients in clinical and research settings.

中文翻译:

MCARDLE 患者 12 分钟步行试验的参考值

在改良的 12 分钟步行测试 (12MWT) 上达到的最大距离是麦卡德尔病糖原贮积病 V 型 (GSDV) 的一项行之有效的措施。年龄、身高、体重和性别是其他患者群体步行距离的已知预测因素。校正这些预测因子的参考值对于个体之间的比较是必要的。迄今为止,尚未对 GSDV 中 12MWT 中的这些预测因子进行系统调查。本研究探讨了这些预测因子对 GSDV 中实现的距离的贡献。从 2011 年至 2017 年间接受 12MWT 的 103 名 GSDV 患者收集了包括最大步行距离、年龄、性别、身高和体重在内的数据。分析显示所达到的距离与身高、年龄、体重和性别之间存在显着相关性。多元线性回归分析显示模型占方差的 29.7%(R = 0.545,R2 0.297,调整后的 R2 0.269)。将身高、年龄和体重纳入回归分析后,性别不显着。这是第一项报告非疾病相关因素对 GSDV 人群中 12MWT 实现距离的贡献的研究。生成的参考值将允许在临床和研究环境中改进对 GSDV 患者的监测和评估。
更新日期:2020-10-01
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